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[Pathogenesis and pathomorphology of human leukodystrophies].
Arkh Patol. 1981; 43(11):86-92.AP

Abstract

A review of foreign literature on the pathogenesis and pathomorphology of hereditary diseases of the human nervous system with the myelin involvement is presented. Five forms of leukodystrophies are mainly dealt with: (1) metachromatic, with the defect of their deposition in the form of a metachromatic substance; (2) globoid, with deficiency of galactoceramide beta-galactase enzyme catabolizing cerebrozides and with accumulation of the latter, particularly in the forming "globoid" cells; (3) sudanophilic, with sudanophilic degeneration of the myelin and obscure defect of the enzyme; (4) Pelizaeus-Merzbacher disease with insularly intact myelin; and (5) adrenoleukodystrophy with sudanophilic degeneration of the myelin and involvement of the adrenals. All the forms of leukodystrophies by the time of the onset of the disease are divided into prenatal, late infantile, juvenile, and adult.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

rus

PubMed ID

7032481

Citation

Zhabotinskiĭ, Iu M., and V F. Shefer. "[Pathogenesis and Pathomorphology of Human Leukodystrophies]." Arkhiv Patologii, vol. 43, no. 11, 1981, pp. 86-92.
Zhabotinskiĭ IuM, Shefer VF. [Pathogenesis and pathomorphology of human leukodystrophies]. Arkh Patol. 1981;43(11):86-92.
Zhabotinskiĭ, I. u. M., & Shefer, V. F. (1981). [Pathogenesis and pathomorphology of human leukodystrophies]. Arkhiv Patologii, 43(11), 86-92.
Zhabotinskiĭ IuM, Shefer VF. [Pathogenesis and Pathomorphology of Human Leukodystrophies]. Arkh Patol. 1981;43(11):86-92. PubMed PMID: 7032481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pathogenesis and pathomorphology of human leukodystrophies]. AU - Zhabotinskiĭ,Iu M, AU - Shefer,V F, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 86 EP - 92 JF - Arkhiv patologii JO - Arkh. Patol. VL - 43 IS - 11 N2 - A review of foreign literature on the pathogenesis and pathomorphology of hereditary diseases of the human nervous system with the myelin involvement is presented. Five forms of leukodystrophies are mainly dealt with: (1) metachromatic, with the defect of their deposition in the form of a metachromatic substance; (2) globoid, with deficiency of galactoceramide beta-galactase enzyme catabolizing cerebrozides and with accumulation of the latter, particularly in the forming "globoid" cells; (3) sudanophilic, with sudanophilic degeneration of the myelin and obscure defect of the enzyme; (4) Pelizaeus-Merzbacher disease with insularly intact myelin; and (5) adrenoleukodystrophy with sudanophilic degeneration of the myelin and involvement of the adrenals. All the forms of leukodystrophies by the time of the onset of the disease are divided into prenatal, late infantile, juvenile, and adult. SN - 0004-1955 UR - https://www.unboundmedicine.com/medline/citation/7032481/[Pathogenesis_and_pathomorphology_of_human_leukodystrophies]_ L2 - https://medlineplus.gov/leukodystrophies.html DB - PRIME DP - Unbound Medicine ER -