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UKEMS trial: bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2uvrA(pKM101) and S. typhimurium TA98 and TA100.
Mutat Res. 1982 Jan-Feb; 100(1-4):39-43.MR

Abstract

4CMB, 4HMB and BC were assayed in plate tests, using E. coli WP2urvA(pKM101), and S. typhimurium TA98 and TA100, in the presence or absence of microsomal activation. 4CMB was also assayed in fluctuation tests using E. coli WP2uvrA(pKM101). 4HMB was uniformly negative, and 4CMB was mutagenic to all 3 strains. BC was negative in TA98 and positive in TA100 and WP2uvrA(pKM101). The presence of absence of S9 made no substantial difference to the mutagenicity of 4CMB or BC.

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Publisher Full Text

Authors

Venitt S
No affiliation info available
Crofton-Sleigh C
No affiliation info available
Bosworth DA
No affiliation info available

MeSH

Benzyl CompoundsBiphenyl CompoundsEscherichia coliMutagenicity TestsMutagensMutationSalmonella typhimuriumSpecies SpecificityStructure-Activity Relationship

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7035896

Citation

Venitt, S, et al. "UKEMS Trial: Bacterial Mutation Tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and Benzyl Chloride, Using E. Coli WP2uvrA(pKM101) and S. Typhimurium TA98 and TA100." Mutation Research, vol. 100, no. 1-4, 1982, pp. 39-43.
Venitt S, Crofton-Sleigh C, Bosworth DA. UKEMS trial: bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2uvrA(pKM101) and S. typhimurium TA98 and TA100. Mutat Res. 1982;100(1-4):39-43.
Venitt, S., Crofton-Sleigh, C., & Bosworth, D. A. (1982). UKEMS trial: bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2uvrA(pKM101) and S. typhimurium TA98 and TA100. Mutation Research, 100(1-4), 39-43.
Venitt S, Crofton-Sleigh C, Bosworth DA. UKEMS Trial: Bacterial Mutation Tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and Benzyl Chloride, Using E. Coli WP2uvrA(pKM101) and S. Typhimurium TA98 and TA100. Mutat Res. 1982 Jan-Feb;100(1-4):39-43. PubMed PMID: 7035896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - UKEMS trial: bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2uvrA(pKM101) and S. typhimurium TA98 and TA100. AU - Venitt,S, AU - Crofton-Sleigh,C, AU - Bosworth,D A, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 39 EP - 43 JF - Mutation research JO - Mutat Res VL - 100 IS - 1-4 N2 - 4CMB, 4HMB and BC were assayed in plate tests, using E. coli WP2urvA(pKM101), and S. typhimurium TA98 and TA100, in the presence or absence of microsomal activation. 4CMB was also assayed in fluctuation tests using E. coli WP2uvrA(pKM101). 4HMB was uniformly negative, and 4CMB was mutagenic to all 3 strains. BC was negative in TA98 and positive in TA100 and WP2uvrA(pKM101). The presence of absence of S9 made no substantial difference to the mutagenicity of 4CMB or BC. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/7035896/UKEMS_trial:_bacterial_mutation_tests_of_4_chloromethylbiphenyl_4_hydroxymethylbiphenyl_and_benzyl_chloride_using_E__coli_WP2uvrA_pKM101__and_S__typhimurium_TA98_and_TA100_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0165-1218(82)90018-0 DB - PRIME DP - Unbound Medicine ER -