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Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex.
Naunyn Schmiedebergs Arch Pharmacol. 1978 Sep; 304(2):107-10.NS

Abstract

The effects of delta9-tetrahydrocannabinol (delta9-THC), the major psychoactive compound of marijuana, and cannabidiol (CBD), a non-psychoactive component, on the acetylcholine (ACh) concentration and the turnover rate of ACh (TRACh) have been studied in various regions of the rat brain. Neither delta9-THC doses from 0.2 to 10 mg/kg nor CBD (10 OR 20 MG/KG) alter the ACh concentration in the brain areas examined 30 min, after the intravenous injection. However, delta9-THC (doses from 0.2 to 10 mg/kg) causes a marked dose-related decrease in the TRACh in hippocampus whereas CBD is without effect in this brain region even when 20 mg/kg is given. Furthermore, high doses of delta9-THC (5 mg/kg) and CBD (20 mg/kg) that produce a significant decrease in the TRACh of striatum fail to change the TRACh in parietal cortex. The low doses of delta9-THC required to reduce hippocampal TRACh suggest that an action on these cholinergic mechanisms may play a role in the psychotomimetic activity of delta9-THC.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

703853

Citation

Revuelta, A V., et al. "Effect of Cannabinoids On the Turnover Rate of Acetylcholine in Rat Hippocampus, Striatum and Cortex." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 304, no. 2, 1978, pp. 107-10.
Revuelta AV, Moroni F, Cheney DL, et al. Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex. Naunyn Schmiedebergs Arch Pharmacol. 1978;304(2):107-10.
Revuelta, A. V., Moroni, F., Cheney, D. L., & Costa, E. (1978). Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex. Naunyn-Schmiedeberg's Archives of Pharmacology, 304(2), 107-10.
Revuelta AV, et al. Effect of Cannabinoids On the Turnover Rate of Acetylcholine in Rat Hippocampus, Striatum and Cortex. Naunyn Schmiedebergs Arch Pharmacol. 1978;304(2):107-10. PubMed PMID: 703853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex. AU - Revuelta,A V, AU - Moroni,F, AU - Cheney,D L, AU - Costa,E, PY - 1978/9/12/pubmed PY - 1978/9/12/medline PY - 1978/9/12/entrez SP - 107 EP - 10 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 304 IS - 2 N2 - The effects of delta9-tetrahydrocannabinol (delta9-THC), the major psychoactive compound of marijuana, and cannabidiol (CBD), a non-psychoactive component, on the acetylcholine (ACh) concentration and the turnover rate of ACh (TRACh) have been studied in various regions of the rat brain. Neither delta9-THC doses from 0.2 to 10 mg/kg nor CBD (10 OR 20 MG/KG) alter the ACh concentration in the brain areas examined 30 min, after the intravenous injection. However, delta9-THC (doses from 0.2 to 10 mg/kg) causes a marked dose-related decrease in the TRACh in hippocampus whereas CBD is without effect in this brain region even when 20 mg/kg is given. Furthermore, high doses of delta9-THC (5 mg/kg) and CBD (20 mg/kg) that produce a significant decrease in the TRACh of striatum fail to change the TRACh in parietal cortex. The low doses of delta9-THC required to reduce hippocampal TRACh suggest that an action on these cholinergic mechanisms may play a role in the psychotomimetic activity of delta9-THC. SN - 0028-1298 UR - https://www.unboundmedicine.com/medline/citation/703853/Effect_of_cannabinoids_on_the_turnover_rate_of_acetylcholine_in_rat_hippocampus_striatum_and_cortex_ DB - PRIME DP - Unbound Medicine ER -