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IgA anti-gliadin antibodies in coeliac disease.
Clin Exp Immunol. 1981 Nov; 46(2):286-93.CE

Abstract

Sixty-two sera from children under investigation for gastrointestinal disease were tested for IgA, IgG and IgM antibodies to gliadin by two different methods: an immunofluorescent (IF) test, and a mixed reverse (solid-phase) passive antiglobulin haemadsorption (MRSPAH) test. There was good agreement between the tests. Both tests detected gliadin antibodies of IgG and IgA class in sera from children with active coeliac disease, which tended to disappear when a strict gluten-free diet was instituted. Serum antibodies to gliadin of IgA class were associated with severe small intestinal villous atrophy and were found almost exclusively in coeliac disease. Gliadin antibodies of IgG class were less disease-specific and were occasionally detected in sera from children with gastrointestinal disease other than coeliac disease--notably in sera from children with transient gluten intolerance.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7039883

Citation

Unsworth, D J., et al. "IgA Anti-gliadin Antibodies in Coeliac Disease." Clinical and Experimental Immunology, vol. 46, no. 2, 1981, pp. 286-93.
Unsworth DJ, Kieffer M, Holborow EJ, et al. IgA anti-gliadin antibodies in coeliac disease. Clin Exp Immunol. 1981;46(2):286-93.
Unsworth, D. J., Kieffer, M., Holborow, E. J., Coombs, R. R., & Walker-Smith, J. A. (1981). IgA anti-gliadin antibodies in coeliac disease. Clinical and Experimental Immunology, 46(2), 286-93.
Unsworth DJ, et al. IgA Anti-gliadin Antibodies in Coeliac Disease. Clin Exp Immunol. 1981;46(2):286-93. PubMed PMID: 7039883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA anti-gliadin antibodies in coeliac disease. AU - Unsworth,D J, AU - Kieffer,M, AU - Holborow,E J, AU - Coombs,R R, AU - Walker-Smith,J A, PY - 1981/11/1/pubmed PY - 1981/11/1/medline PY - 1981/11/1/entrez SP - 286 EP - 93 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 46 IS - 2 N2 - Sixty-two sera from children under investigation for gastrointestinal disease were tested for IgA, IgG and IgM antibodies to gliadin by two different methods: an immunofluorescent (IF) test, and a mixed reverse (solid-phase) passive antiglobulin haemadsorption (MRSPAH) test. There was good agreement between the tests. Both tests detected gliadin antibodies of IgG and IgA class in sera from children with active coeliac disease, which tended to disappear when a strict gluten-free diet was instituted. Serum antibodies to gliadin of IgA class were associated with severe small intestinal villous atrophy and were found almost exclusively in coeliac disease. Gliadin antibodies of IgG class were less disease-specific and were occasionally detected in sera from children with gastrointestinal disease other than coeliac disease--notably in sera from children with transient gluten intolerance. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/7039883/IgA_anti_gliadin_antibodies_in_coeliac_disease_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7039883/ DB - PRIME DP - Unbound Medicine ER -