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Effects on the efferent ducts in Macaca mulatta.
Am J Pathol. 1982 Jun; 107(3):310-5.AJ

Abstract

Immunopathologic findings in efferent ducts of 36 rhesus macaques vasectomized as many as 12 years earlier and of 11 age-matched control animals were compared. Electron-microscopic observation of these ducts revealed changes after vasectomy. The epithelium shortened from a prevasectomy height of 25 mu to 14 mu as the ducts stretched after vasectomy. The number of sperm and macrophages in the lumen increased. The basement membrane was 300-700 A wide in nonvasectomized animals but several times that in animals vasectomized 6 or more years before; the mean width significantly increased with time after vasectomy. Numerous electron-dense immune complexes were found within the thickened lamina in 33% of vasectomized animals and in none of the controls. The mean size of the electron-dense areas varied from 0.01 sq mu in a monkey vasectomized 3 years earlier to 0.18 sq mu in an animal vasectomized 7 years earlier; the mean area significantly increased with time after vasectomy. Frozen sections of testis and epididymis were evaluated through the use of fluorescein-conjugated antibodies. Of the nonvasectomized controls, 18% showed immune deposits. Of the vasectomized animals, 53% revealed C3 deposition in the basement membrane surrounding the efferent ducts. The presence of electron-dense deposits plus the finding of putative immune complexes as revealed by immunofluorescence suggested that vasectomy enhances leakage of sperm antigens, particularly in the region of the efferent duct.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7044132

Citation

Marsh, L D., and N J. Alexander. "Effects On the Efferent Ducts in Macaca Mulatta." The American Journal of Pathology, vol. 107, no. 3, 1982, pp. 310-5.
Marsh LD, Alexander NJ. Effects on the efferent ducts in Macaca mulatta. Am J Pathol. 1982;107(3):310-5.
Marsh, L. D., & Alexander, N. J. (1982). Effects on the efferent ducts in Macaca mulatta. The American Journal of Pathology, 107(3), 310-5.
Marsh LD, Alexander NJ. Effects On the Efferent Ducts in Macaca Mulatta. Am J Pathol. 1982;107(3):310-5. PubMed PMID: 7044132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects on the efferent ducts in Macaca mulatta. AU - Marsh,L D, AU - Alexander,N J, PY - 1982/6/1/pubmed PY - 1982/6/1/medline PY - 1982/6/1/entrez SP - 310 EP - 5 JF - The American journal of pathology JO - Am J Pathol VL - 107 IS - 3 N2 - Immunopathologic findings in efferent ducts of 36 rhesus macaques vasectomized as many as 12 years earlier and of 11 age-matched control animals were compared. Electron-microscopic observation of these ducts revealed changes after vasectomy. The epithelium shortened from a prevasectomy height of 25 mu to 14 mu as the ducts stretched after vasectomy. The number of sperm and macrophages in the lumen increased. The basement membrane was 300-700 A wide in nonvasectomized animals but several times that in animals vasectomized 6 or more years before; the mean width significantly increased with time after vasectomy. Numerous electron-dense immune complexes were found within the thickened lamina in 33% of vasectomized animals and in none of the controls. The mean size of the electron-dense areas varied from 0.01 sq mu in a monkey vasectomized 3 years earlier to 0.18 sq mu in an animal vasectomized 7 years earlier; the mean area significantly increased with time after vasectomy. Frozen sections of testis and epididymis were evaluated through the use of fluorescein-conjugated antibodies. Of the nonvasectomized controls, 18% showed immune deposits. Of the vasectomized animals, 53% revealed C3 deposition in the basement membrane surrounding the efferent ducts. The presence of electron-dense deposits plus the finding of putative immune complexes as revealed by immunofluorescence suggested that vasectomy enhances leakage of sperm antigens, particularly in the region of the efferent duct. SN - 0002-9440 UR - https://www.unboundmedicine.com/medline/citation/7044132/Effects_on_the_efferent_ducts_in_Macaca_mulatta_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7044132/ DB - PRIME DP - Unbound Medicine ER -