Tags

Type your tag names separated by a space and hit enter

Endocrine pancreatic response of children with onset of insulin-requiring diabetes before age 3 and after age 5.
J Pediatr. 1982 Jul; 101(1):36-9.JPed

Abstract

The increased incidence of severe hypoglycemia reported in young children with diabetes is consistent with a defect in glucagon secretion or a generalized abnormality in islet hormone secretion. To assess pancreatic hormone and gastric inhibitory polypeptide secretion in children with early onset diabetes, 12 children with onset of diabetes prior to the age of 28 months were studied and the data compared to the hormone responses observed in 11 children with LOD, diagnosed after the age of 5 years. Plasma glucose, C-peptide, glucagon, pancreatic polypeptide, and gastric inhibitory peptide concentrations were measured during and following an arginine infusion (500 mg/kg over 60 minutes) and a mixed meal. During arginine infusion, plasma glucose and glucagon increased similarly in both groups and returned to basal concentrations following discontinuation of arginine infusion. In contrast, plasma C-peptide, hPP, and GIP concentrations did not change. Following the mixed meal plasma glucose, hPP, and GIP concentrations increased similarly in the two groups of children, but no change was observed in either plasma glucagon or C-peptide concentrations in either group. These data demonstrate that EOD and LOD are associated with insulin insufficiency alone and that abnormalities in secretion of other pancreatic islet hormone or GIP cannot be implicated in the high incidence of severe hypoglycemia observed in children with EOD.

Links

Publisher Full Text

Authors

Ternand C
No affiliation info available
Go VL
No affiliation info available
Gerich JE
No affiliation info available
Haymond MW
No affiliation info available

MeSH

ArginineBlood GlucoseC-PeptideChildChild, PreschoolDiabetes MellitusDiabetes Mellitus, Type 1FemaleGastric Inhibitory PolypeptideGlucagonHumansHypoglycemiaInfantInfusions, ParenteralInsulinIslets of LangerhansMalePancreatic PolypeptideTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7045315

Citation

Ternand, C, et al. "Endocrine Pancreatic Response of Children With Onset of Insulin-requiring Diabetes Before Age 3 and After Age 5." The Journal of Pediatrics, vol. 101, no. 1, 1982, pp. 36-9.
Ternand C, Go VL, Gerich JE, et al. Endocrine pancreatic response of children with onset of insulin-requiring diabetes before age 3 and after age 5. J Pediatr. 1982;101(1):36-9.
Ternand, C., Go, V. L., Gerich, J. E., & Haymond, M. W. (1982). Endocrine pancreatic response of children with onset of insulin-requiring diabetes before age 3 and after age 5. The Journal of Pediatrics, 101(1), 36-9.
Ternand C, et al. Endocrine Pancreatic Response of Children With Onset of Insulin-requiring Diabetes Before Age 3 and After Age 5. J Pediatr. 1982;101(1):36-9. PubMed PMID: 7045315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine pancreatic response of children with onset of insulin-requiring diabetes before age 3 and after age 5. AU - Ternand,C, AU - Go,V L, AU - Gerich,J E, AU - Haymond,M W, PY - 1982/7/1/pubmed PY - 1982/7/1/medline PY - 1982/7/1/entrez SP - 36 EP - 9 JF - The Journal of pediatrics JO - J Pediatr VL - 101 IS - 1 N2 - The increased incidence of severe hypoglycemia reported in young children with diabetes is consistent with a defect in glucagon secretion or a generalized abnormality in islet hormone secretion. To assess pancreatic hormone and gastric inhibitory polypeptide secretion in children with early onset diabetes, 12 children with onset of diabetes prior to the age of 28 months were studied and the data compared to the hormone responses observed in 11 children with LOD, diagnosed after the age of 5 years. Plasma glucose, C-peptide, glucagon, pancreatic polypeptide, and gastric inhibitory peptide concentrations were measured during and following an arginine infusion (500 mg/kg over 60 minutes) and a mixed meal. During arginine infusion, plasma glucose and glucagon increased similarly in both groups and returned to basal concentrations following discontinuation of arginine infusion. In contrast, plasma C-peptide, hPP, and GIP concentrations did not change. Following the mixed meal plasma glucose, hPP, and GIP concentrations increased similarly in the two groups of children, but no change was observed in either plasma glucagon or C-peptide concentrations in either group. These data demonstrate that EOD and LOD are associated with insulin insufficiency alone and that abnormalities in secretion of other pancreatic islet hormone or GIP cannot be implicated in the high incidence of severe hypoglycemia observed in children with EOD. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/7045315/Endocrine_pancreatic_response_of_children_with_onset_of_insulin_requiring_diabetes_before_age_3_and_after_age_5_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(82)80176-5 DB - PRIME DP - Unbound Medicine ER -