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A controlled comparison of the antihypertensive effects of labetalol and alpha-methyldopa.
Pharmatherapeutica. 1982; 3(2):133-9.P

Abstract

An open crossover study was carried out in 10 Arab patients with mild to moderate hypertension to compare the effectiveness and tolerability of labetalol with alpha-methyldopa. Patients were started on either 100 mg labetalol or 250 mg alpha-methyldopa 3-times daily and, if necessary, the dosage adjusted by standard increments every 2 weeks over a period of a month until satisfactory control was achieved. This dosage was then maintained for a further 6 weeks before the patients were crossed over to the alternative treatment, similarly adjusted, after a wash-out period of 2 weeks on placebo. The results showed that both treatments produced effective blood pressure control and there was no significant difference in the maximum reduction achieved. The effect of the two drugs on heart rate was also similar. Both treatments were generally well-tolerated and side-effects were mild and similar with either drug.

Authors

Al-Damluji SF
No affiliation info available
Al-Khalidi A
No affiliation info available
Shaarbaf H
No affiliation info available
Tawfiq NH
No affiliation info available

MeSH

AdultBlood PressureClinical Trials as TopicEthanolaminesFemaleHeart RateHumansHypertensionLabetalolMaleMethyldopaMiddle Aged

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7048338

Citation

Al-Damluji, S F., et al. "A Controlled Comparison of the Antihypertensive Effects of Labetalol and Alpha-methyldopa." Pharmatherapeutica, vol. 3, no. 2, 1982, pp. 133-9.
Al-Damluji SF, Al-Khalidi A, Shaarbaf H, et al. A controlled comparison of the antihypertensive effects of labetalol and alpha-methyldopa. Pharmatherapeutica. 1982;3(2):133-9.
Al-Damluji, S. F., Al-Khalidi, A., Shaarbaf, H., & Tawfiq, N. H. (1982). A controlled comparison of the antihypertensive effects of labetalol and alpha-methyldopa. Pharmatherapeutica, 3(2), 133-9.
Al-Damluji SF, et al. A Controlled Comparison of the Antihypertensive Effects of Labetalol and Alpha-methyldopa. Pharmatherapeutica. 1982;3(2):133-9. PubMed PMID: 7048338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A controlled comparison of the antihypertensive effects of labetalol and alpha-methyldopa. AU - Al-Damluji,S F, AU - Al-Khalidi,A, AU - Shaarbaf,H, AU - Tawfiq,N H, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 133 EP - 9 JF - Pharmatherapeutica JO - Pharmatherapeutica VL - 3 IS - 2 N2 - An open crossover study was carried out in 10 Arab patients with mild to moderate hypertension to compare the effectiveness and tolerability of labetalol with alpha-methyldopa. Patients were started on either 100 mg labetalol or 250 mg alpha-methyldopa 3-times daily and, if necessary, the dosage adjusted by standard increments every 2 weeks over a period of a month until satisfactory control was achieved. This dosage was then maintained for a further 6 weeks before the patients were crossed over to the alternative treatment, similarly adjusted, after a wash-out period of 2 weeks on placebo. The results showed that both treatments produced effective blood pressure control and there was no significant difference in the maximum reduction achieved. The effect of the two drugs on heart rate was also similar. Both treatments were generally well-tolerated and side-effects were mild and similar with either drug. SN - 0308-051X UR - https://www.unboundmedicine.com/medline/citation/7048338/A_controlled_comparison_of_the_antihypertensive_effects_of_labetalol_and_alpha_methyldopa_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -