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Mutagenicity of hydrolysates of citrus fruit juices.
Mutat Res. 1982 Jun; 101(4):283-91.MR

Abstract

Hydrolysates of citrus fruit juice were mutagenic according to the Ames test. The citrus fruit juices were hydrolysed with 1 M HCl, hesperidinase, naringinase and human intestinal bacteria. The hydrolysates were successively extracted with n-hexane, chloroform, diethyl ether and ethyl acetate. The mutagenicities of extracts were assayed by the Ames test, and the mutagens were analysed by gas chromatography and mass spectrometry (GC-MS). Mutagenicities of hydrolysates of citrus fruit juice were found in both the chloroform extracts and the ether extracts. The chloroform extracts were mutagenic to TA98 and TA100 with S9 mix, and the ether extracts were mutagenic to TA98 and TA100 with or without S9 mix. Some known flavonols such as kaempferol and quercetin were detected in the extracts of the hydrolysates by GC-MS. It is suggested that the mutagenicity of the extracts originated from those flavonols in the citrus fruit juice.

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Publisher Full Text

Authors

Mazaki M
No affiliation info available
Ishii T
No affiliation info available
Uyeta M
No affiliation info available

MeSH

FlavonoidsFood HandlingFruitGas Chromatography-Mass SpectrometryKaempferolsMutagenicity TestsMutagensMutationQuercetinSalmonella typhimuriumSpecies Specificity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7050681

Citation

Mazaki, M, et al. "Mutagenicity of Hydrolysates of Citrus Fruit Juices." Mutation Research, vol. 101, no. 4, 1982, pp. 283-91.
Mazaki M, Ishii T, Uyeta M. Mutagenicity of hydrolysates of citrus fruit juices. Mutat Res. 1982;101(4):283-91.
Mazaki, M., Ishii, T., & Uyeta, M. (1982). Mutagenicity of hydrolysates of citrus fruit juices. Mutation Research, 101(4), 283-91.
Mazaki M, Ishii T, Uyeta M. Mutagenicity of Hydrolysates of Citrus Fruit Juices. Mutat Res. 1982;101(4):283-91. PubMed PMID: 7050681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutagenicity of hydrolysates of citrus fruit juices. AU - Mazaki,M, AU - Ishii,T, AU - Uyeta,M, PY - 1982/6/1/pubmed PY - 1982/6/1/medline PY - 1982/6/1/entrez SP - 283 EP - 91 JF - Mutation research JO - Mutat Res VL - 101 IS - 4 N2 - Hydrolysates of citrus fruit juice were mutagenic according to the Ames test. The citrus fruit juices were hydrolysed with 1 M HCl, hesperidinase, naringinase and human intestinal bacteria. The hydrolysates were successively extracted with n-hexane, chloroform, diethyl ether and ethyl acetate. The mutagenicities of extracts were assayed by the Ames test, and the mutagens were analysed by gas chromatography and mass spectrometry (GC-MS). Mutagenicities of hydrolysates of citrus fruit juice were found in both the chloroform extracts and the ether extracts. The chloroform extracts were mutagenic to TA98 and TA100 with S9 mix, and the ether extracts were mutagenic to TA98 and TA100 with or without S9 mix. Some known flavonols such as kaempferol and quercetin were detected in the extracts of the hydrolysates by GC-MS. It is suggested that the mutagenicity of the extracts originated from those flavonols in the citrus fruit juice. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/7050681/Mutagenicity_of_hydrolysates_of_citrus_fruit_juices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0165-1218(82)90121-5 DB - PRIME DP - Unbound Medicine ER -