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A putative 5-HT central feedback in migraine and cluster headache attacks.
Adv Neurol. 1982; 33:265-74.AN

Abstract

5-HT is considered to play a role in the migraine mechanism; its decrease in the midbrain during migraine attacks has been postulated. CSF TP and plasma and platelet 5-HT levels in migraine and cluster headache sufferers have been evaluated; the values registered were compared to those of neurological and carcinoid patients, respectively. The following results were obtained: (a) no significant difference in the time course of free and total TP after l-TP intravenous loading, (b) increased levels of CSF TP during migraine and cluster headache attacks, (c) impressively increased levels of plasma 5-HT only in carcinoid patients. These findings suggest the existence of a positive 5-HT central feedback mechanism during attacks of migraine and cluster headache and thus exclude peripheral 5-HT effects in the generation of pain.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7055005

Citation

Salmon, S, et al. "A Putative 5-HT Central Feedback in Migraine and Cluster Headache Attacks." Advances in Neurology, vol. 33, 1982, pp. 265-74.
Salmon S, Bonciani M, Fanciullacci M, et al. A putative 5-HT central feedback in migraine and cluster headache attacks. Adv Neurol. 1982;33:265-74.
Salmon, S., Bonciani, M., Fanciullacci, M., Marianelli, L., Michelacci, S., & Sicuteri, F. (1982). A putative 5-HT central feedback in migraine and cluster headache attacks. Advances in Neurology, 33, 265-74.
Salmon S, et al. A Putative 5-HT Central Feedback in Migraine and Cluster Headache Attacks. Adv Neurol. 1982;33:265-74. PubMed PMID: 7055005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A putative 5-HT central feedback in migraine and cluster headache attacks. AU - Salmon,S, AU - Bonciani,M, AU - Fanciullacci,M, AU - Marianelli,L, AU - Michelacci,S, AU - Sicuteri,F, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 265 EP - 74 JF - Advances in neurology JO - Adv Neurol VL - 33 N2 - 5-HT is considered to play a role in the migraine mechanism; its decrease in the midbrain during migraine attacks has been postulated. CSF TP and plasma and platelet 5-HT levels in migraine and cluster headache sufferers have been evaluated; the values registered were compared to those of neurological and carcinoid patients, respectively. The following results were obtained: (a) no significant difference in the time course of free and total TP after l-TP intravenous loading, (b) increased levels of CSF TP during migraine and cluster headache attacks, (c) impressively increased levels of plasma 5-HT only in carcinoid patients. These findings suggest the existence of a positive 5-HT central feedback mechanism during attacks of migraine and cluster headache and thus exclude peripheral 5-HT effects in the generation of pain. SN - 0091-3952 UR - https://www.unboundmedicine.com/medline/citation/7055005/A_putative_5_HT_central_feedback_in_migraine_and_cluster_headache_attacks_ L2 - http://www.diseaseinfosearch.org/result/9556 DB - PRIME DP - Unbound Medicine ER -