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Autonomic control of the immediate heart rate response to lying down.
Clin Sci (Lond). 1982 Jan; 62(1):57-64.CS

Abstract

1. The initial heart rate response to lying down was analysed in 18 younger (23-36 years) and 10 older (48-67 years) normal subjects, and consisted of an immediate shortening of the R-R interval reaching a maximum around the third or fourth beat after lying, followed by a lengthening beyond the resting value to reach a steady level around beats 25-30. In six diabetic patients with autonomic neuropathy, no cardiac acceleration occurred and the deceleration was markedly diminished. 2. In eight young normal subjects the pattern of response was altered by atropine, which abolished the initial shortening of the R-R interval over the first 10 beats. Thereafter slow but steady lengthening of the R-R interval occurred. With additional propranolol the later part of the response was further attenuated. Propranolol alone did not affect the normal pattern of response. 3. Six young normal subjects performed short periods of muscular exercise, lying, sitting and standing, and the heart rate patterns were compared with that after lying down. After both manoeuvres R-R interval shortened and then lengthened back to the resting level within 10-15 beats. Thereafter it remained steady after muscular exercise, but continued to lengthen after lying down. 4. In four young normal subjects, no initial R-R interval shortening occurred during fast or slow "passive' tilting from the 80 degrees head-up position to horizontal, whereas shortening was seen both with fast and slow "active' lying down. 5. It is concluded that the immediate part of the heart rate response to lying down (during the first 10 beats) is under vagal control and the later part predominantly under sympathetic control. The first part of the response is probably due to a "muscle-heart' reflex which occurs during the change in posture.

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Publisher Full Text

Authors

Bellavere F
No affiliation info available
Ewing DJ
No affiliation info available

MeSH

AdultAgedAtropineAutonomic Nerve BlockAutonomic Nervous SystemAutonomic Nervous System DiseasesDiabetic NeuropathiesHeart RateHumansMaleMiddle AgedPhysical ExertionPosturePropranolol

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7056031

Citation

Bellavere, F, and D J. Ewing. "Autonomic Control of the Immediate Heart Rate Response to Lying Down." Clinical Science (London, England : 1979), vol. 62, no. 1, 1982, pp. 57-64.
Bellavere F, Ewing DJ. Autonomic control of the immediate heart rate response to lying down. Clin Sci (Lond). 1982;62(1):57-64.
Bellavere, F., & Ewing, D. J. (1982). Autonomic control of the immediate heart rate response to lying down. Clinical Science (London, England : 1979), 62(1), 57-64.
Bellavere F, Ewing DJ. Autonomic Control of the Immediate Heart Rate Response to Lying Down. Clin Sci (Lond). 1982;62(1):57-64. PubMed PMID: 7056031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic control of the immediate heart rate response to lying down. AU - Bellavere,F, AU - Ewing,D J, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 57 EP - 64 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 62 IS - 1 N2 - 1. The initial heart rate response to lying down was analysed in 18 younger (23-36 years) and 10 older (48-67 years) normal subjects, and consisted of an immediate shortening of the R-R interval reaching a maximum around the third or fourth beat after lying, followed by a lengthening beyond the resting value to reach a steady level around beats 25-30. In six diabetic patients with autonomic neuropathy, no cardiac acceleration occurred and the deceleration was markedly diminished. 2. In eight young normal subjects the pattern of response was altered by atropine, which abolished the initial shortening of the R-R interval over the first 10 beats. Thereafter slow but steady lengthening of the R-R interval occurred. With additional propranolol the later part of the response was further attenuated. Propranolol alone did not affect the normal pattern of response. 3. Six young normal subjects performed short periods of muscular exercise, lying, sitting and standing, and the heart rate patterns were compared with that after lying down. After both manoeuvres R-R interval shortened and then lengthened back to the resting level within 10-15 beats. Thereafter it remained steady after muscular exercise, but continued to lengthen after lying down. 4. In four young normal subjects, no initial R-R interval shortening occurred during fast or slow "passive' tilting from the 80 degrees head-up position to horizontal, whereas shortening was seen both with fast and slow "active' lying down. 5. It is concluded that the immediate part of the heart rate response to lying down (during the first 10 beats) is under vagal control and the later part predominantly under sympathetic control. The first part of the response is probably due to a "muscle-heart' reflex which occurs during the change in posture. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/7056031/Autonomic_control_of_the_immediate_heart_rate_response_to_lying_down_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/cs0620057 DB - PRIME DP - Unbound Medicine ER -