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Distribution of melanosomes across the retinal pigment epithelium of a hooded rat: implications for light damage.
Invest Ophthalmol Vis Sci 1982; 22(2):139-44IO

Abstract

Distribution of melanosomes across the retinal pigment epithelium of hooded rats (Long-Evans) is studied at the light microscopic and electron microscopic levels. This distribution is shown to be nonuniform: more melanosomes exist in the periphery than elsewhere and, importantly, there are very few melanosomes in a restricted area of the central portion of the superior hemisphere compared with the corresponding part of the inferior hemisphere. The region with fewest melanosomes is precisely the one that is highly susceptible to light damage. Because this region is the same in both pigmented and albino eyes, the paucity of melanin in this region is not the cause of its great sensitivity to light damage. Nor does light cause the nonuniform distribution of melanin. A possible explanation, involving a proposed vestigial tapetum, is given in order to explain the correlation of melanosome counts and sensitivity to light damage.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7056629

Citation

Howell, W L., et al. "Distribution of Melanosomes Across the Retinal Pigment Epithelium of a Hooded Rat: Implications for Light Damage." Investigative Ophthalmology & Visual Science, vol. 22, no. 2, 1982, pp. 139-44.
Howell WL, Rapp LM, Williams TP. Distribution of melanosomes across the retinal pigment epithelium of a hooded rat: implications for light damage. Invest Ophthalmol Vis Sci. 1982;22(2):139-44.
Howell, W. L., Rapp, L. M., & Williams, T. P. (1982). Distribution of melanosomes across the retinal pigment epithelium of a hooded rat: implications for light damage. Investigative Ophthalmology & Visual Science, 22(2), pp. 139-44.
Howell WL, Rapp LM, Williams TP. Distribution of Melanosomes Across the Retinal Pigment Epithelium of a Hooded Rat: Implications for Light Damage. Invest Ophthalmol Vis Sci. 1982;22(2):139-44. PubMed PMID: 7056629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of melanosomes across the retinal pigment epithelium of a hooded rat: implications for light damage. AU - Howell,W L, AU - Rapp,L M, AU - Williams,T P, PY - 1982/2/1/pubmed PY - 1982/2/1/medline PY - 1982/2/1/entrez SP - 139 EP - 44 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 22 IS - 2 N2 - Distribution of melanosomes across the retinal pigment epithelium of hooded rats (Long-Evans) is studied at the light microscopic and electron microscopic levels. This distribution is shown to be nonuniform: more melanosomes exist in the periphery than elsewhere and, importantly, there are very few melanosomes in a restricted area of the central portion of the superior hemisphere compared with the corresponding part of the inferior hemisphere. The region with fewest melanosomes is precisely the one that is highly susceptible to light damage. Because this region is the same in both pigmented and albino eyes, the paucity of melanin in this region is not the cause of its great sensitivity to light damage. Nor does light cause the nonuniform distribution of melanin. A possible explanation, involving a proposed vestigial tapetum, is given in order to explain the correlation of melanosome counts and sensitivity to light damage. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/7056629/Distribution_of_melanosomes_across_the_retinal_pigment_epithelium_of_a_hooded_rat:_implications_for_light_damage_ L2 - http://iovs.arvojournals.org/article.aspx?volume=22&page=139 DB - PRIME DP - Unbound Medicine ER -