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Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain.
J Pharmacol Exp Ther. 1982 Feb; 220(2):322-8.JP

Abstract

Phosphatidylcholine (PCh) administered intragastrically to rats resulted in prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained with a relatively narrow range irrespective of the Ch concentration.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7057393

Citation

Jope, R S.. "Effects of Phosphatidylcholine Administration to Rats On Choline in Blood and Choline and Acetylcholine in Brain." The Journal of Pharmacology and Experimental Therapeutics, vol. 220, no. 2, 1982, pp. 322-8.
Jope RS. Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. J Pharmacol Exp Ther. 1982;220(2):322-8.
Jope, R. S. (1982). Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. The Journal of Pharmacology and Experimental Therapeutics, 220(2), 322-8.
Jope RS. Effects of Phosphatidylcholine Administration to Rats On Choline in Blood and Choline and Acetylcholine in Brain. J Pharmacol Exp Ther. 1982;220(2):322-8. PubMed PMID: 7057393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. A1 - Jope,R S, PY - 1982/2/1/pubmed PY - 1982/2/1/medline PY - 1982/2/1/entrez SP - 322 EP - 8 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 220 IS - 2 N2 - Phosphatidylcholine (PCh) administered intragastrically to rats resulted in prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained with a relatively narrow range irrespective of the Ch concentration. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/7057393/Effects_of_phosphatidylcholine_administration_to_rats_on_choline_in_blood_and_choline_and_acetylcholine_in_brain_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7057393 DB - PRIME DP - Unbound Medicine ER -