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Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat.
Gastroenterology. 1982 May; 82(5 Pt 1):864-70.G

Abstract

Controlled clinical trials have shown that tripotassium dicitrato bismuthate healed duodenal and gastric ulcers significantly better than placebo. One mechanism suggested is that it forms a protective coat at the ulcer base. We studied this coating action in rats with chronic gastric ulcers produced by a standardized technique for mucosal wounding at the fundoantral junction. Bismuth was identified by histochemical staining using Castel's reagent, the specificity of which was verified in vitro against 13 other metallic compounds and chemicals. Our results showed that tripotassium dicitrato bismuthate had a coating affinity for the ulcer base, but not for the adjacent normal mucosa. All rats treated with tripotassium dicitrato bismuthate 1, 2, 4, and 6 h previously, but not the control rats treated with water or those treated with four other bismuth compounds, manifested a layer of bismuth that coated the ulcer base. Light and electron microscopy of the tripotassium dicitrato bismuthate-treated ulcers--but not their controls-revealed an abundance of macrophages, which had ingested the bismuth. This unique bismuth coat may insulate the ulcer base from acid-pepsin digestion, while the influx of macrophages may expedite reparative processes.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7060908

Citation

Koo, J, et al. "Selective Coating of Gastric Ulcer By Tripotassium Dicitrato Bismuthate in the Rat." Gastroenterology, vol. 82, no. 5 Pt 1, 1982, pp. 864-70.
Koo J, Ho J, Lam SK, et al. Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat. Gastroenterology. 1982;82(5 Pt 1):864-70.
Koo, J., Ho, J., Lam, S. K., Wong, J., & Ong, G. B. (1982). Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat. Gastroenterology, 82(5 Pt 1), 864-70.
Koo J, et al. Selective Coating of Gastric Ulcer By Tripotassium Dicitrato Bismuthate in the Rat. Gastroenterology. 1982;82(5 Pt 1):864-70. PubMed PMID: 7060908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat. AU - Koo,J, AU - Ho,J, AU - Lam,S K, AU - Wong,J, AU - Ong,G B, PY - 1982/5/1/pubmed PY - 1982/5/1/medline PY - 1982/5/1/entrez SP - 864 EP - 70 JF - Gastroenterology JO - Gastroenterology VL - 82 IS - 5 Pt 1 N2 - Controlled clinical trials have shown that tripotassium dicitrato bismuthate healed duodenal and gastric ulcers significantly better than placebo. One mechanism suggested is that it forms a protective coat at the ulcer base. We studied this coating action in rats with chronic gastric ulcers produced by a standardized technique for mucosal wounding at the fundoantral junction. Bismuth was identified by histochemical staining using Castel's reagent, the specificity of which was verified in vitro against 13 other metallic compounds and chemicals. Our results showed that tripotassium dicitrato bismuthate had a coating affinity for the ulcer base, but not for the adjacent normal mucosa. All rats treated with tripotassium dicitrato bismuthate 1, 2, 4, and 6 h previously, but not the control rats treated with water or those treated with four other bismuth compounds, manifested a layer of bismuth that coated the ulcer base. Light and electron microscopy of the tripotassium dicitrato bismuthate-treated ulcers--but not their controls-revealed an abundance of macrophages, which had ingested the bismuth. This unique bismuth coat may insulate the ulcer base from acid-pepsin digestion, while the influx of macrophages may expedite reparative processes. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/7060908/Selective_coating_of_gastric_ulcer_by_tripotassium_dicitrato_bismuthate_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508582000948 DB - PRIME DP - Unbound Medicine ER -