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Resection of gastrinoma in the Zollinger-Ellison syndrome.
Gastroenterology. 1982 May; 82(5 Pt 1):953-6.G

Abstract

Patients with the Zollinger-Ellison syndrome have been managed by total gastrectomy and more recently, by the use of H2-receptor antagonists. An alternative approach has been to identify those who might be cured by excision of a pancreatic islet-cell tumor without removal of the stomach. The course of such a patient is reported. A 40-yr-old man with massive gastric hypersecretion, acid-peptic disease, diarrhea, and elevated serum gastrin was treated by excising a pancreatic gastrinoma. Serum gastrin and gastric secretion became and have remained normal for 7 yr. Symptoms ceased and provocative tests with secretin and calcium have remained normal. Three additional patients with Zollinger-Ellison syndrome in whom pancreatic islet-cell tumor resection alone has resulted in long-term cures have been identified. All were middle-aged men with severe diarrhea. These successes, the availability of techniques that permit early identification and localization of gastrinomas, and the advent of H2-receptor antagonists that can control gastric hypersecretion without gastrectomy must be considered in managing patients with gastrinomas.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7060915

Citation

Barreras, R F., et al. "Resection of Gastrinoma in the Zollinger-Ellison Syndrome." Gastroenterology, vol. 82, no. 5 Pt 1, 1982, pp. 953-6.
Barreras RF, Mack E, Goodfriend T, et al. Resection of gastrinoma in the Zollinger-Ellison syndrome. Gastroenterology. 1982;82(5 Pt 1):953-6.
Barreras, R. F., Mack, E., Goodfriend, T., & Damm, M. (1982). Resection of gastrinoma in the Zollinger-Ellison syndrome. Gastroenterology, 82(5 Pt 1), 953-6.
Barreras RF, et al. Resection of Gastrinoma in the Zollinger-Ellison Syndrome. Gastroenterology. 1982;82(5 Pt 1):953-6. PubMed PMID: 7060915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resection of gastrinoma in the Zollinger-Ellison syndrome. AU - Barreras,R F, AU - Mack,E, AU - Goodfriend,T, AU - Damm,M, PY - 1982/5/1/pubmed PY - 1982/5/1/medline PY - 1982/5/1/entrez SP - 953 EP - 6 JF - Gastroenterology JO - Gastroenterology VL - 82 IS - 5 Pt 1 N2 - Patients with the Zollinger-Ellison syndrome have been managed by total gastrectomy and more recently, by the use of H2-receptor antagonists. An alternative approach has been to identify those who might be cured by excision of a pancreatic islet-cell tumor without removal of the stomach. The course of such a patient is reported. A 40-yr-old man with massive gastric hypersecretion, acid-peptic disease, diarrhea, and elevated serum gastrin was treated by excising a pancreatic gastrinoma. Serum gastrin and gastric secretion became and have remained normal for 7 yr. Symptoms ceased and provocative tests with secretin and calcium have remained normal. Three additional patients with Zollinger-Ellison syndrome in whom pancreatic islet-cell tumor resection alone has resulted in long-term cures have been identified. All were middle-aged men with severe diarrhea. These successes, the availability of techniques that permit early identification and localization of gastrinomas, and the advent of H2-receptor antagonists that can control gastric hypersecretion without gastrectomy must be considered in managing patients with gastrinomas. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/7060915/Resection_of_gastrinoma_in_the_Zollinger_Ellison_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508582001012 DB - PRIME DP - Unbound Medicine ER -