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Discriminative stimulus properties of DOM and several molecular modifications.
Pharmacol Biochem Behav. 1982 Apr; 16(4):553-6.PB

Abstract

Rats trained to discriminate racemic 2,5-dimethoxy-4-methylphenylisopropylamine, (+/-)-DOM (1.0 mg/kg), from saline in a two-lever drug discrimination task were challenged with the optimal isomers of DOM as well as with several related agents which represent minor molecular modifications of the DOM structure. Generalization of the (+/-)-DOM stimulus was found to occur to R(-)-DOM, S(+)-DOM, (+/-)-2,5-dimethoxyphenylisopropylamine (2,5-DMA), R(-)-2,-5-DMA, and the 2-demethyl derivative of (+/-)-DOM. The 3-methyl positional isomer of (+/-)-DOM was found to produce only 34% DOM-appropriate responding at the highest dose tested while administration of S(+)-2,5-DMA and the 5-demethyl derivative of (+/-)-DOM resulted in disruption of behavior.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7071088

Citation

Glennon, R A., et al. "Discriminative Stimulus Properties of DOM and Several Molecular Modifications." Pharmacology, Biochemistry, and Behavior, vol. 16, no. 4, 1982, pp. 553-6.
Glennon RA, Young R, Rosecrans JA. Discriminative stimulus properties of DOM and several molecular modifications. Pharmacol Biochem Behav. 1982;16(4):553-6.
Glennon, R. A., Young, R., & Rosecrans, J. A. (1982). Discriminative stimulus properties of DOM and several molecular modifications. Pharmacology, Biochemistry, and Behavior, 16(4), 553-6.
Glennon RA, Young R, Rosecrans JA. Discriminative Stimulus Properties of DOM and Several Molecular Modifications. Pharmacol Biochem Behav. 1982;16(4):553-6. PubMed PMID: 7071088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative stimulus properties of DOM and several molecular modifications. AU - Glennon,R A, AU - Young,R, AU - Rosecrans,J A, PY - 1982/4/1/pubmed PY - 1982/4/1/medline PY - 1982/4/1/entrez SP - 553 EP - 6 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 16 IS - 4 N2 - Rats trained to discriminate racemic 2,5-dimethoxy-4-methylphenylisopropylamine, (+/-)-DOM (1.0 mg/kg), from saline in a two-lever drug discrimination task were challenged with the optimal isomers of DOM as well as with several related agents which represent minor molecular modifications of the DOM structure. Generalization of the (+/-)-DOM stimulus was found to occur to R(-)-DOM, S(+)-DOM, (+/-)-2,5-dimethoxyphenylisopropylamine (2,5-DMA), R(-)-2,-5-DMA, and the 2-demethyl derivative of (+/-)-DOM. The 3-methyl positional isomer of (+/-)-DOM was found to produce only 34% DOM-appropriate responding at the highest dose tested while administration of S(+)-2,5-DMA and the 5-demethyl derivative of (+/-)-DOM resulted in disruption of behavior. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/7071088/Discriminative_stimulus_properties_of_DOM_and_several_molecular_modifications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(82)90413-0 DB - PRIME DP - Unbound Medicine ER -