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Evaluation of erythrocyte protoporphyrin and zinc protoporphyrin as micro screening procedures for lead poisoning detection.
Ann Clin Biochem. 1982 Mar; 19(Pt 2):71-6.AC

Abstract

Seven hundred and three blood samples from children were analysed for lead by Delves cup atomic absorption, for protoporphyrin by solvent extraction and fluorescence, and for zinc protoporphyrin with two manufacturers' models of automated front-face fluorimeter (haemato-fluorimeter). This power of protoporphyrin analysis for predicting the level of lead in blood was found to be poor. Up to 30% of children with lead concentrations of greater than or equal to 40 g/100 ml (greater than or equal to 1.93 mumol/l) and nearly 60% of children with greater than or equal to 30 microgram/100 ml (greater than or equal to 1.45 mumol/l) would remain undetected if protoporphyrin analysis were used for screening with an action level of 60 microgram/100 ml (1.07 mumol/l) for the porphyrin analysis. The predictive power of protoporphyrin analyses improves with the age of the child, indicating that the less expensive protoporphyrin test may be acceptable for older children, if by this means a large population of children at risk can be screened.

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Publisher Full Text

Authors

Bush B
No affiliation info available
Doran DR
No affiliation info available
Jackson KW
No affiliation info available

MeSH

ChildChild, PreschoolErythrocytesHumansInfantLead PoisoningPorphyrinsProtoporphyrins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7073218

Citation

Bush, B, et al. "Evaluation of Erythrocyte Protoporphyrin and Zinc Protoporphyrin as Micro Screening Procedures for Lead Poisoning Detection." Annals of Clinical Biochemistry, vol. 19, no. Pt 2, 1982, pp. 71-6.
Bush B, Doran DR, Jackson KW. Evaluation of erythrocyte protoporphyrin and zinc protoporphyrin as micro screening procedures for lead poisoning detection. Ann Clin Biochem. 1982;19(Pt 2):71-6.
Bush, B., Doran, D. R., & Jackson, K. W. (1982). Evaluation of erythrocyte protoporphyrin and zinc protoporphyrin as micro screening procedures for lead poisoning detection. Annals of Clinical Biochemistry, 19(Pt 2), 71-6.
Bush B, Doran DR, Jackson KW. Evaluation of Erythrocyte Protoporphyrin and Zinc Protoporphyrin as Micro Screening Procedures for Lead Poisoning Detection. Ann Clin Biochem. 1982;19(Pt 2):71-6. PubMed PMID: 7073218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of erythrocyte protoporphyrin and zinc protoporphyrin as micro screening procedures for lead poisoning detection. AU - Bush,B, AU - Doran,D R, AU - Jackson,K W, PY - 1982/3/1/pubmed PY - 1982/3/1/medline PY - 1982/3/1/entrez SP - 71 EP - 6 JF - Annals of clinical biochemistry JO - Ann Clin Biochem VL - 19 IS - Pt 2 N2 - Seven hundred and three blood samples from children were analysed for lead by Delves cup atomic absorption, for protoporphyrin by solvent extraction and fluorescence, and for zinc protoporphyrin with two manufacturers' models of automated front-face fluorimeter (haemato-fluorimeter). This power of protoporphyrin analysis for predicting the level of lead in blood was found to be poor. Up to 30% of children with lead concentrations of greater than or equal to 40 g/100 ml (greater than or equal to 1.93 mumol/l) and nearly 60% of children with greater than or equal to 30 microgram/100 ml (greater than or equal to 1.45 mumol/l) would remain undetected if protoporphyrin analysis were used for screening with an action level of 60 microgram/100 ml (1.07 mumol/l) for the porphyrin analysis. The predictive power of protoporphyrin analyses improves with the age of the child, indicating that the less expensive protoporphyrin test may be acceptable for older children, if by this means a large population of children at risk can be screened. SN - 0004-5632 UR - https://www.unboundmedicine.com/medline/citation/7073218/Evaluation_of_erythrocyte_protoporphyrin_and_zinc_protoporphyrin_as_micro_screening_procedures_for_lead_poisoning_detection_ L2 - https://journals.sagepub.com/doi/10.1177/000456328201900202?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -