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[Changes in the diagnosis and treatment of Zollinger-Ellison syndrome (author's transl)].
Dtsch Med Wochenschr. 1982 May 07; 107(18):697-704.DM

Abstract

A gastrinoma was found in 12 of 23 patients with Zollinger-Ellison syndrome. Those with gastrinoma were not different from those without as regarded fasting gastrin level, increased gastrin secretion after secretin and calcium, acid secretion, or survival time. Five of the 23 patients have died, four immediately postoperatively, the fifth of the metastasizing tumour. Treatment with the H2-receptor antagonist cimetidine avoided emergency operation and thus decreased operative mortality, giving time for localization by ultrasound, computed tomography and selective arteriography. The rate of false-negative results was high. Transhepatic selective catheterization of the pancreatic veins with gastrin determination gives localization of the tumour and identification of the secreted hormone. In three patients tumour resection was possible under cover of H2-receptor antagonist administration which normalized gastrin and acid secretion. There is a change in the treatment of the Zollinger-Ellison syndrome, away from total gastrectomy to conservative treatment with H2-receptor antagonists and an attempt of curative treatment by removal of the tumour.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

7075486

Citation

Feurle, G E., et al. "[Changes in the Diagnosis and Treatment of Zollinger-Ellison Syndrome (author's Transl)]." Deutsche Medizinische Wochenschrift (1946), vol. 107, no. 18, 1982, pp. 697-704.
Feurle GE, Helmstädter V, Hoevels J, et al. [Changes in the diagnosis and treatment of Zollinger-Ellison syndrome (author's transl)]. Dtsch Med Wochenschr. 1982;107(18):697-704.
Feurle, G. E., Helmstädter, V., Hoevels, J., Wenzel-Herzer, G., & Klempa, I. (1982). [Changes in the diagnosis and treatment of Zollinger-Ellison syndrome (author's transl)]. Deutsche Medizinische Wochenschrift (1946), 107(18), 697-704.
Feurle GE, et al. [Changes in the Diagnosis and Treatment of Zollinger-Ellison Syndrome (author's Transl)]. Dtsch Med Wochenschr. 1982 May 7;107(18):697-704. PubMed PMID: 7075486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes in the diagnosis and treatment of Zollinger-Ellison syndrome (author's transl)]. AU - Feurle,G E, AU - Helmstädter,V, AU - Hoevels,J, AU - Wenzel-Herzer,G, AU - Klempa,I, PY - 1982/5/7/pubmed PY - 1982/5/7/medline PY - 1982/5/7/entrez SP - 697 EP - 704 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 107 IS - 18 N2 - A gastrinoma was found in 12 of 23 patients with Zollinger-Ellison syndrome. Those with gastrinoma were not different from those without as regarded fasting gastrin level, increased gastrin secretion after secretin and calcium, acid secretion, or survival time. Five of the 23 patients have died, four immediately postoperatively, the fifth of the metastasizing tumour. Treatment with the H2-receptor antagonist cimetidine avoided emergency operation and thus decreased operative mortality, giving time for localization by ultrasound, computed tomography and selective arteriography. The rate of false-negative results was high. Transhepatic selective catheterization of the pancreatic veins with gastrin determination gives localization of the tumour and identification of the secreted hormone. In three patients tumour resection was possible under cover of H2-receptor antagonist administration which normalized gastrin and acid secretion. There is a change in the treatment of the Zollinger-Ellison syndrome, away from total gastrectomy to conservative treatment with H2-receptor antagonists and an attempt of curative treatment by removal of the tumour. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/7075486/[Changes_in_the_diagnosis_and_treatment_of_Zollinger_Ellison_syndrome__author's_transl_]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1070006 DB - PRIME DP - Unbound Medicine ER -