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[GABA-ergic cortical component in the action of piracetam and cetyl GABA].
Biull Eksp Biol Med. 1982 Apr; 93(4):62-4.BE

Abstract

The effect of piracetam on the electrophysiological and biochemical characteristics of the GABA system was studied and compared to that of cethyl ether of GABA (CEGABA). It was shown that piracetam (250-500 mg/kg) enhances the test response depression in the primary response recovery cycle and produces synchronization of the ECoG of the sensomotor cortex similarly to the previously described GABA-positive substances. The synchronizing effects of piracetam are retained upon isolation of the cortex and can be removed by bicucullin (rather than by strychnine) applied to the cortex. Piracetam decreases the GABA content in the brain cortex and inhibits the activity of glutamate decarboxylase. Analogous effect is exerted by CEGABA. A conclusion is drawn that GABA-ergic processes get potentiated under the effect of both the drugs. The selectivity of piracetam effects as to the cortical GABA-ergic inhibitory systems is likely to be the reason for the absence in the drug of anticonvulsant effect inherent in GABA mimetics with more generalized effects (CEGABA, muscimol).

Authors

Ostrovskaia RU
No affiliation info available
Molodavkin GM
No affiliation info available
Kovalev GI
No affiliation info available

MeSH

AnimalsBicucullineCatsCerebral CortexElectroencephalographyGABA AntagonistsMalePiracetamPyrrolidinonesRatsRats, Inbred StrainsReceptors, DrugStrychninegamma-Aminobutyric Acid

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

7082805

Citation

Ostrovskaia, R U., et al. "[GABA-ergic Cortical Component in the Action of Piracetam and Cetyl GABA]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 93, no. 4, 1982, pp. 62-4.
Ostrovskaia RU, Molodavkin GM, Kovalev GI. [GABA-ergic cortical component in the action of piracetam and cetyl GABA]. Biull Eksp Biol Med. 1982;93(4):62-4.
Ostrovskaia, R. U., Molodavkin, G. M., & Kovalev, G. I. (1982). [GABA-ergic cortical component in the action of piracetam and cetyl GABA]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 93(4), 62-4.
Ostrovskaia RU, Molodavkin GM, Kovalev GI. [GABA-ergic Cortical Component in the Action of Piracetam and Cetyl GABA]. Biull Eksp Biol Med. 1982;93(4):62-4. PubMed PMID: 7082805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [GABA-ergic cortical component in the action of piracetam and cetyl GABA]. AU - Ostrovskaia,R U, AU - Molodavkin,G M, AU - Kovalev,G I, PY - 1982/4/1/pubmed PY - 1982/4/1/medline PY - 1982/4/1/entrez SP - 62 EP - 4 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 93 IS - 4 N2 - The effect of piracetam on the electrophysiological and biochemical characteristics of the GABA system was studied and compared to that of cethyl ether of GABA (CEGABA). It was shown that piracetam (250-500 mg/kg) enhances the test response depression in the primary response recovery cycle and produces synchronization of the ECoG of the sensomotor cortex similarly to the previously described GABA-positive substances. The synchronizing effects of piracetam are retained upon isolation of the cortex and can be removed by bicucullin (rather than by strychnine) applied to the cortex. Piracetam decreases the GABA content in the brain cortex and inhibits the activity of glutamate decarboxylase. Analogous effect is exerted by CEGABA. A conclusion is drawn that GABA-ergic processes get potentiated under the effect of both the drugs. The selectivity of piracetam effects as to the cortical GABA-ergic inhibitory systems is likely to be the reason for the absence in the drug of anticonvulsant effect inherent in GABA mimetics with more generalized effects (CEGABA, muscimol). SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/7082805/[GABA_ergic_cortical_component_in_the_action_of_piracetam_and_cetyl_GABA]_ DB - PRIME DP - Unbound Medicine ER -