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Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid quantitation.
Blood. 1982 Jun; 59(6):1128-31.Blood

Abstract

A study was made to assess the value of cobalamin deficiency detection through quantitation of urinary methylmalonic acid (MMA). Urinary MMA was measured in 1118 patients suffering from megaloblastic anemia, other anemias, elevated red cell mean corpuscular volume, or unexplained neurologic disorders. Patients without proven cobalamin deficiency had urinary MMA levels less than 20 micrograms/ml. All patients (n = 27) confirmed to have cobalamin deficiency showed MMA levels greater than 20 micrograms/ml. Data are presented showing the Schilling test results, the comparison of serum cobalamin to urinary MMA levels, and other basic hematologic data. MMA levels are a good indication of cobalamin distribution and function since they are directly related to a cobalamin-dependent metabolic pathway. With rapid, reliable quantitation by mass spectrometry, urinary MMA can now be a useful clinical test.

Links

Publisher Full Text
linkinghub.elsevier.com
ashpublications.org

Authors

Norman EJ
No affiliation info available
Martelo OJ
No affiliation info available
Denton MD
No affiliation info available

MeSH

AdultAgedFemaleHumansMaleMalonatesMethylmalonic AcidMiddle AgedVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7082819

Citation

Norman, E J., et al. "Cobalamin (vitamin B12) Deficiency Detection By Urinary Methylmalonic Acid Quantitation." Blood, vol. 59, no. 6, 1982, pp. 1128-31.
Norman EJ, Martelo OJ, Denton MD. Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid quantitation. Blood. 1982;59(6):1128-31.
Norman, E. J., Martelo, O. J., & Denton, M. D. (1982). Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid quantitation. Blood, 59(6), 1128-31.
Norman EJ, Martelo OJ, Denton MD. Cobalamin (vitamin B12) Deficiency Detection By Urinary Methylmalonic Acid Quantitation. Blood. 1982;59(6):1128-31. PubMed PMID: 7082819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid quantitation. AU - Norman,E J, AU - Martelo,O J, AU - Denton,M D, PY - 1982/6/1/pubmed PY - 1982/6/1/medline PY - 1982/6/1/entrez SP - 1128 EP - 31 JF - Blood JO - Blood VL - 59 IS - 6 N2 - A study was made to assess the value of cobalamin deficiency detection through quantitation of urinary methylmalonic acid (MMA). Urinary MMA was measured in 1118 patients suffering from megaloblastic anemia, other anemias, elevated red cell mean corpuscular volume, or unexplained neurologic disorders. Patients without proven cobalamin deficiency had urinary MMA levels less than 20 micrograms/ml. All patients (n = 27) confirmed to have cobalamin deficiency showed MMA levels greater than 20 micrograms/ml. Data are presented showing the Schilling test results, the comparison of serum cobalamin to urinary MMA levels, and other basic hematologic data. MMA levels are a good indication of cobalamin distribution and function since they are directly related to a cobalamin-dependent metabolic pathway. With rapid, reliable quantitation by mass spectrometry, urinary MMA can now be a useful clinical test. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/7082819/Cobalamin__vitamin_B12__deficiency_detection_by_urinary_methylmalonic_acid_quantitation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-4971(20)76022-2 DB - PRIME DP - Unbound Medicine ER -