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Cow's milk formula as a cause of infantile colic: a double-blind study.

Abstract

The role of cow's milk in infantile colic in formula-fed infants was estimated in a double-blind study. Sixty colicky infants were given a cow's milk-containing formula (Enfamil) and a cow's milk-free formula based on soy (ProSobee). Eleven infants (18%) were free of symptoms while receiving soy formula. Symptoms of 32 infants (53%) were unchanged or worse when they were fed cow's milk formula and soy formula, but symptoms disappeared when they were fed a formula containing hydrolyzed casein (Nutramigen). Symptoms of 17 infants (29%) could not be related to the diet; these infants were permitted to continue on a cow's milk-based formula. A challenge with cow's milk-based formula after one month (at approximately age 3 months) produced symptoms of infantile colic in 22 infants (36%). At age 6 months, a challenge with cow's milk was positive in 11 infants (18%) with epidermal and gastrointestinal symptoms. Eight infants (13%) at 12 months of age and five infants (8%) at 16 months of age were still intolerant to cow's milk. Cow's milk seems to be a major cause of infantile colic in formula-fed infants. A dietary treatment is suggested for moderate or severe forms of the colic. Cow's milk protein intolerance is common later in infancy in these infants.

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  • Publisher Full Text
  • Authors

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    Source

    Pediatrics 70:1 1982 Jul pg 7-10

    MeSH

    Animals
    Cattle
    Colic
    Double-Blind Method
    Female
    Food Hypersensitivity
    Gastrointestinal Diseases
    Humans
    Infant
    Infant Food
    Infant, Newborn
    Male
    Milk

    Pub Type(s)

    Clinical Trial
    Controlled Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    7088636

    Citation

    Lothe, L, et al. "Cow's Milk Formula as a Cause of Infantile Colic: a Double-blind Study." Pediatrics, vol. 70, no. 1, 1982, pp. 7-10.
    Lothe L, Lindberg T, Jakobsson I. Cow's milk formula as a cause of infantile colic: a double-blind study. Pediatrics. 1982;70(1):7-10.
    Lothe, L., Lindberg, T., & Jakobsson, I. (1982). Cow's milk formula as a cause of infantile colic: a double-blind study. Pediatrics, 70(1), pp. 7-10.
    Lothe L, Lindberg T, Jakobsson I. Cow's Milk Formula as a Cause of Infantile Colic: a Double-blind Study. Pediatrics. 1982;70(1):7-10. PubMed PMID: 7088636.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cow's milk formula as a cause of infantile colic: a double-blind study. AU - Lothe,L, AU - Lindberg,T, AU - Jakobsson,I, PY - 1982/7/1/pubmed PY - 1982/7/1/medline PY - 1982/7/1/entrez SP - 7 EP - 10 JF - Pediatrics JO - Pediatrics VL - 70 IS - 1 N2 - The role of cow's milk in infantile colic in formula-fed infants was estimated in a double-blind study. Sixty colicky infants were given a cow's milk-containing formula (Enfamil) and a cow's milk-free formula based on soy (ProSobee). Eleven infants (18%) were free of symptoms while receiving soy formula. Symptoms of 32 infants (53%) were unchanged or worse when they were fed cow's milk formula and soy formula, but symptoms disappeared when they were fed a formula containing hydrolyzed casein (Nutramigen). Symptoms of 17 infants (29%) could not be related to the diet; these infants were permitted to continue on a cow's milk-based formula. A challenge with cow's milk-based formula after one month (at approximately age 3 months) produced symptoms of infantile colic in 22 infants (36%). At age 6 months, a challenge with cow's milk was positive in 11 infants (18%) with epidermal and gastrointestinal symptoms. Eight infants (13%) at 12 months of age and five infants (8%) at 16 months of age were still intolerant to cow's milk. Cow's milk seems to be a major cause of infantile colic in formula-fed infants. A dietary treatment is suggested for moderate or severe forms of the colic. Cow's milk protein intolerance is common later in infancy in these infants. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/7088636/Cow's_milk_formula_as_a_cause_of_infantile_colic:_a_double_blind_study_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=7088636 DB - PRIME DP - Unbound Medicine ER -