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Kinetics of [3H]choline and [3H]acetylcholine metabolism in several regions of rat brain following intracerebroventricular injection of [3H]choline. Effects of haloperidol.
Biochem Pharmacol. 1982 Apr 15; 31(8):1599-605.BP

Abstract

Intracerebroventricular (icv.) injection of [3H]choline in conscious rats produced a rapid, efficient labeling of brain choline and acetylcholine (ACh) stores without altering steady-state levels of endogenous ACh. The kinetics of [3H]choline and [3H]ACh metabolism were measured in seven brain regions for up to 10 min following icv. administration of [3H]choline. The initial rate of formation of [3H]ACh varied in different brain areas, being greatest in the striatum and least in the hypothalamus. In contrast, the rate of [3H]choline metabolism was similar in all regions of the brain. Pretreatment of rats with haloperidol resulted in an increase in the apparent synthesis rate of ACh only in the striatum and rostral hypothalamus, pointing to possible dopaminergic-cholinergic interaction in these regions.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7092951

Citation

Buccafusco, J J.. "Kinetics of [3H]choline and [3H]acetylcholine Metabolism in Several Regions of Rat Brain Following Intracerebroventricular Injection of [3H]choline. Effects of Haloperidol." Biochemical Pharmacology, vol. 31, no. 8, 1982, pp. 1599-605.
Buccafusco JJ. Kinetics of [3H]choline and [3H]acetylcholine metabolism in several regions of rat brain following intracerebroventricular injection of [3H]choline. Effects of haloperidol. Biochem Pharmacol. 1982;31(8):1599-605.
Buccafusco, J. J. (1982). Kinetics of [3H]choline and [3H]acetylcholine metabolism in several regions of rat brain following intracerebroventricular injection of [3H]choline. Effects of haloperidol. Biochemical Pharmacology, 31(8), 1599-605.
Buccafusco JJ. Kinetics of [3H]choline and [3H]acetylcholine Metabolism in Several Regions of Rat Brain Following Intracerebroventricular Injection of [3H]choline. Effects of Haloperidol. Biochem Pharmacol. 1982 Apr 15;31(8):1599-605. PubMed PMID: 7092951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics of [3H]choline and [3H]acetylcholine metabolism in several regions of rat brain following intracerebroventricular injection of [3H]choline. Effects of haloperidol. A1 - Buccafusco,J J, PY - 1982/4/15/pubmed PY - 1982/4/15/medline PY - 1982/4/15/entrez SP - 1599 EP - 605 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 31 IS - 8 N2 - Intracerebroventricular (icv.) injection of [3H]choline in conscious rats produced a rapid, efficient labeling of brain choline and acetylcholine (ACh) stores without altering steady-state levels of endogenous ACh. The kinetics of [3H]choline and [3H]ACh metabolism were measured in seven brain regions for up to 10 min following icv. administration of [3H]choline. The initial rate of formation of [3H]ACh varied in different brain areas, being greatest in the striatum and least in the hypothalamus. In contrast, the rate of [3H]choline metabolism was similar in all regions of the brain. Pretreatment of rats with haloperidol resulted in an increase in the apparent synthesis rate of ACh only in the striatum and rostral hypothalamus, pointing to possible dopaminergic-cholinergic interaction in these regions. SN - 0006-2952 UR - https://www.unboundmedicine.com/medline/citation/7092951/Kinetics_of_[3H]choline_and_[3H]acetylcholine_metabolism_in_several_regions_of_rat_brain_following_intracerebroventricular_injection_of_[3H]choline__Effects_of_haloperidol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-2952(82)90387-2 DB - PRIME DP - Unbound Medicine ER -