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Overt iron deficiency in sickle cell disease.
Arch Intern Med 1982; 142(9):1621-4AI

Abstract

Overt iron deficiency was diagnosed in four patients with sickle cell disease. Three patients had homozygous SS and one had hemoglobin SC disease. The cause in each case was proved or suspected blood loss. Iron repletion was accompanied by increases in the blood hemoglobin and hematocrit levels, erythrocyte mean corpuscular volume, and mean corpuscular hemoglobin concentration (MCHC) and by change in the RBC morphologic characteristics from hypochromic microcytic to normochromic normocytic. The diagnosis of iron deficiency was confirmed by the finding of a low serum ferritin level, a high serum total iron-binding capacity, or both. Two patients who had had no painful crises while they were iron deficient began having crises again, and another patient had painful crises for the first time after the blood values improved. Whether a lowered MCHC is beneficial to patients with sickle cell diseases is an important but unanswered question.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7114979

Citation

Haddy, T B., and O Castro. "Overt Iron Deficiency in Sickle Cell Disease." Archives of Internal Medicine, vol. 142, no. 9, 1982, pp. 1621-4.
Haddy TB, Castro O. Overt iron deficiency in sickle cell disease. Arch Intern Med. 1982;142(9):1621-4.
Haddy, T. B., & Castro, O. (1982). Overt iron deficiency in sickle cell disease. Archives of Internal Medicine, 142(9), pp. 1621-4.
Haddy TB, Castro O. Overt Iron Deficiency in Sickle Cell Disease. Arch Intern Med. 1982;142(9):1621-4. PubMed PMID: 7114979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overt iron deficiency in sickle cell disease. AU - Haddy,T B, AU - Castro,O, PY - 1982/9/1/pubmed PY - 1982/9/1/medline PY - 1982/9/1/entrez SP - 1621 EP - 4 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 142 IS - 9 N2 - Overt iron deficiency was diagnosed in four patients with sickle cell disease. Three patients had homozygous SS and one had hemoglobin SC disease. The cause in each case was proved or suspected blood loss. Iron repletion was accompanied by increases in the blood hemoglobin and hematocrit levels, erythrocyte mean corpuscular volume, and mean corpuscular hemoglobin concentration (MCHC) and by change in the RBC morphologic characteristics from hypochromic microcytic to normochromic normocytic. The diagnosis of iron deficiency was confirmed by the finding of a low serum ferritin level, a high serum total iron-binding capacity, or both. Two patients who had had no painful crises while they were iron deficient began having crises again, and another patient had painful crises for the first time after the blood values improved. Whether a lowered MCHC is beneficial to patients with sickle cell diseases is an important but unanswered question. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/7114979/Overt_iron_deficiency_in_sickle_cell_disease_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/142/pg/1621 DB - PRIME DP - Unbound Medicine ER -