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Heterogeneity of red cells in the sickler: a characteristic with practical clinical and pathophysiological implications.
Blood Cells. 1982; 8(1):9-15.BC

Abstract

The role of heterogeneity of red cells and its relation to the severity of sickle cell anemia has been examined by the use of spontaneously formed continuous density gradients. We have found that sicklers have a more heterogeneous distribution of cell densities than normals; that this heterogeneity varies greatly from patient to patient; and that this heterogeneity is functionally significant because it involves changes in MCHC and O2 affinity. Extrapolation of HbS solution data to clinical situations will have to account for heterogeneity, and previous efforts to correlate ISC's with severity might have ignored the role of cells with high density but without the classical morphological features associated with these types of cells.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7115982

Citation

Fabry, M E., and R L. Nagel. "Heterogeneity of Red Cells in the Sickler: a Characteristic With Practical Clinical and Pathophysiological Implications." Blood Cells, vol. 8, no. 1, 1982, pp. 9-15.
Fabry ME, Nagel RL. Heterogeneity of red cells in the sickler: a characteristic with practical clinical and pathophysiological implications. Blood Cells. 1982;8(1):9-15.
Fabry, M. E., & Nagel, R. L. (1982). Heterogeneity of red cells in the sickler: a characteristic with practical clinical and pathophysiological implications. Blood Cells, 8(1), 9-15.
Fabry ME, Nagel RL. Heterogeneity of Red Cells in the Sickler: a Characteristic With Practical Clinical and Pathophysiological Implications. Blood Cells. 1982;8(1):9-15. PubMed PMID: 7115982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterogeneity of red cells in the sickler: a characteristic with practical clinical and pathophysiological implications. AU - Fabry,M E, AU - Nagel,R L, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 9 EP - 15 JF - Blood cells JO - Blood Cells VL - 8 IS - 1 N2 - The role of heterogeneity of red cells and its relation to the severity of sickle cell anemia has been examined by the use of spontaneously formed continuous density gradients. We have found that sicklers have a more heterogeneous distribution of cell densities than normals; that this heterogeneity varies greatly from patient to patient; and that this heterogeneity is functionally significant because it involves changes in MCHC and O2 affinity. Extrapolation of HbS solution data to clinical situations will have to account for heterogeneity, and previous efforts to correlate ISC's with severity might have ignored the role of cells with high density but without the classical morphological features associated with these types of cells. SN - 0340-4684 UR - https://www.unboundmedicine.com/medline/citation/7115982/Heterogeneity_of_red_cells_in_the_sickler:_a_characteristic_with_practical_clinical_and_pathophysiological_implications_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:7115982 DB - PRIME DP - Unbound Medicine ER -