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The role of surgery in children with the Zollinger-Ellison syndrome.
Surgery. 1982 Oct; 92(4):682-92.S

Abstract

Long-term follow-up of children with the Zollinger-Ellison syndrome (gastrinomas) suggests that surgical management is still advantageous. Twenty-eight children with the Zollinger-Ellison syndrome have been followed up to 21 years after their initial surgical procedure. Six of seven children with less than total gastrectomy, all of whom underwent operation before the introduction of histamine H2-receptor antagonists, are known dead from complications of continued gastric hypersecretion and tumor growth. Sixteen children had a total gastrectomy, with no operative deaths, and only one died of progressive tumor growth, even though 14 had evidence of metastatic islet-cell carcinoma. Follow-up serum gastrin measurements have been obtained for 13 patients with total gastrectomy, and 5 patients now have a normal serum gastrin levels. Malignant gastrinomas in children have been slow growing, indolent, and compatible with long life. The biologic behavior of malignant gastrinomas appears to be more favorable in the young patient. Total gastrectomy can be done safely in children with the Zollinger-Ellison syndrome and effectively controls gastric hypersecretion when all gastrin-producing tumor cannot be excised. Surgical exploration and an attempt at "curative" tumor excision, even when tumor is extrapancreatic and in lymph nodes, appear worthwhile in selected patients.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7123488

Citation

Wilson, S D.. "The Role of Surgery in Children With the Zollinger-Ellison Syndrome." Surgery, vol. 92, no. 4, 1982, pp. 682-92.
Wilson SD. The role of surgery in children with the Zollinger-Ellison syndrome. Surgery. 1982;92(4):682-92.
Wilson, S. D. (1982). The role of surgery in children with the Zollinger-Ellison syndrome. Surgery, 92(4), 682-92.
Wilson SD. The Role of Surgery in Children With the Zollinger-Ellison Syndrome. Surgery. 1982;92(4):682-92. PubMed PMID: 7123488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of surgery in children with the Zollinger-Ellison syndrome. A1 - Wilson,S D, PY - 1982/10/1/pubmed PY - 1982/10/1/medline PY - 1982/10/1/entrez SP - 682 EP - 92 JF - Surgery JO - Surgery VL - 92 IS - 4 N2 - Long-term follow-up of children with the Zollinger-Ellison syndrome (gastrinomas) suggests that surgical management is still advantageous. Twenty-eight children with the Zollinger-Ellison syndrome have been followed up to 21 years after their initial surgical procedure. Six of seven children with less than total gastrectomy, all of whom underwent operation before the introduction of histamine H2-receptor antagonists, are known dead from complications of continued gastric hypersecretion and tumor growth. Sixteen children had a total gastrectomy, with no operative deaths, and only one died of progressive tumor growth, even though 14 had evidence of metastatic islet-cell carcinoma. Follow-up serum gastrin measurements have been obtained for 13 patients with total gastrectomy, and 5 patients now have a normal serum gastrin levels. Malignant gastrinomas in children have been slow growing, indolent, and compatible with long life. The biologic behavior of malignant gastrinomas appears to be more favorable in the young patient. Total gastrectomy can be done safely in children with the Zollinger-Ellison syndrome and effectively controls gastric hypersecretion when all gastrin-producing tumor cannot be excised. Surgical exploration and an attempt at "curative" tumor excision, even when tumor is extrapancreatic and in lymph nodes, appear worthwhile in selected patients. SN - 0039-6060 UR - https://www.unboundmedicine.com/medline/citation/7123488/The_role_of_surgery_in_children_with_the_Zollinger_Ellison_syndrome_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -