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Prophylactic intravenous ephedrine infusion during spinal anesthesia for cesarean section.
Anesth Analg. 1982 Oct; 61(10):839-42.A&A

Abstract

Ephedrine sulfate was administered to 44 healthy parturients undergoing elective repeat cesarean section under spinal anesthesia. Twenty patients received ephedrine infusion (0.01% solution, beginning with approximately 5 mg/min) immediately after induction of spinal anesthesia to maintain maternal systolic blood pressure between 90% and 100% of the base line systolic blood pressure (mean dose of ephedrine 31.6 mg). Twenty-four patients (control group) received 20 mg of ephedrine as an intravenous bolus, and additional 10-mg increments, if necessary when systolic blood pressure decreased to 80% of the base line systolic blood pressure (mean dose of ephedrine 26.8 mg). In patients given the infusion, systolic blood pressure did not change significantly from the base line systolic blood pressure following spinal anesthesia (p greater than 0.1) and reactive hypertension did not occur. Nausea and/or vomiting occurred in nine women in the control group and one patient in the infusion group (p less than 0.01). Apgar scores, fetal blood gas tensions, and time for onset of respiration were comparable in the two groups. The results suggest that prophylactic ephedrine infusion is safe and desirable in healthy parturients undergoing cesarean section under spinal anesthesia.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7125249

Citation

Kang, Y G., et al. "Prophylactic Intravenous Ephedrine Infusion During Spinal Anesthesia for Cesarean Section." Anesthesia and Analgesia, vol. 61, no. 10, 1982, pp. 839-42.
Kang YG, Abouleish E, Caritis S. Prophylactic intravenous ephedrine infusion during spinal anesthesia for cesarean section. Anesth Analg. 1982;61(10):839-42.
Kang, Y. G., Abouleish, E., & Caritis, S. (1982). Prophylactic intravenous ephedrine infusion during spinal anesthesia for cesarean section. Anesthesia and Analgesia, 61(10), 839-42.
Kang YG, Abouleish E, Caritis S. Prophylactic Intravenous Ephedrine Infusion During Spinal Anesthesia for Cesarean Section. Anesth Analg. 1982;61(10):839-42. PubMed PMID: 7125249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylactic intravenous ephedrine infusion during spinal anesthesia for cesarean section. AU - Kang,Y G, AU - Abouleish,E, AU - Caritis,S, PY - 1982/10/1/pubmed PY - 1982/10/1/medline PY - 1982/10/1/entrez SP - 839 EP - 42 JF - Anesthesia and analgesia JO - Anesth. Analg. VL - 61 IS - 10 N2 - Ephedrine sulfate was administered to 44 healthy parturients undergoing elective repeat cesarean section under spinal anesthesia. Twenty patients received ephedrine infusion (0.01% solution, beginning with approximately 5 mg/min) immediately after induction of spinal anesthesia to maintain maternal systolic blood pressure between 90% and 100% of the base line systolic blood pressure (mean dose of ephedrine 31.6 mg). Twenty-four patients (control group) received 20 mg of ephedrine as an intravenous bolus, and additional 10-mg increments, if necessary when systolic blood pressure decreased to 80% of the base line systolic blood pressure (mean dose of ephedrine 26.8 mg). In patients given the infusion, systolic blood pressure did not change significantly from the base line systolic blood pressure following spinal anesthesia (p greater than 0.1) and reactive hypertension did not occur. Nausea and/or vomiting occurred in nine women in the control group and one patient in the infusion group (p less than 0.01). Apgar scores, fetal blood gas tensions, and time for onset of respiration were comparable in the two groups. The results suggest that prophylactic ephedrine infusion is safe and desirable in healthy parturients undergoing cesarean section under spinal anesthesia. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/7125249/Prophylactic_intravenous_ephedrine_infusion_during_spinal_anesthesia_for_cesarean_section_ L2 - http://Insights.ovid.com/pubmed?pmid=7125249 DB - PRIME DP - Unbound Medicine ER -