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Influence of polyunsaturated fats on composition of plasma lipoproteins and apolipoproteins.
J Lipid Res. 1982 Aug; 23(6):811-22.JL

Abstract

The mechanisms of the hypocholesterolemic effect of polyunsaturated fats (PUSF) are not well understood. One possibility is that these fats uniquely reduce the cholesterol content of lipoproteins. The present study was carried out to determine specifically whether the ratio of cholesterol-to-protein (or apoB) in LDL (or other lipoproteins) is reduced by PUSF; also, lipoprotein composition was examined for other possible changes. Eight men and two women with different levels of plasma cholesterol were studied on the metabolic ward for 8 weeks. They were given a diet high in saturated fats (SF) for 4 weeks and another rich in PUSF for 4 weeks. On PUSF diets, mean plasma cholesterol decreased by 25% (SF = 296 +/- 27 (SEM) vs. PUSF = 223 +/- 21 mg/dl) as did total plasma apoB (155 +/- 8 vs. 116 +/- 13 mg/dl). LDL-Cholesterol decreased by 26%, and LDL-apoB fell by 29%. The mean ratio of cholesterol-to-apoB did not change significantly (SF = 1.52 +/- 0.04 vs. PUSF = 1.48 +/- 0.07). Likewise, HDL-cholesterol decreased by 15% (SF = 51 +/- 5 vs. PUSF = 43 +/- 4 mg/dl), and total plasma apoA-I was reduced by 19% (95 +/- 15 vs. 77 +/- 6 mg/dl); also, no change in the cholesterol-to-apoA-I in HDL was noted. Finally, there were no changes in cholesterol/apoB or triglyceride/apoB ratios in VLDL despite a 23% decrease in plasma triglycerides on PUSF. Thus, the hypocholesterolemic effect of PUSF was uniform for all lipoproteins and usually was accompanied by a corresponding decrease in concentrations of apoprotein constituents.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7130852

Citation

Vega, G L., et al. "Influence of Polyunsaturated Fats On Composition of Plasma Lipoproteins and Apolipoproteins." Journal of Lipid Research, vol. 23, no. 6, 1982, pp. 811-22.
Vega GL, Groszek E, Wolf R, et al. Influence of polyunsaturated fats on composition of plasma lipoproteins and apolipoproteins. J Lipid Res. 1982;23(6):811-22.
Vega, G. L., Groszek, E., Wolf, R., & Grundy, S. M. (1982). Influence of polyunsaturated fats on composition of plasma lipoproteins and apolipoproteins. Journal of Lipid Research, 23(6), 811-22.
Vega GL, et al. Influence of Polyunsaturated Fats On Composition of Plasma Lipoproteins and Apolipoproteins. J Lipid Res. 1982;23(6):811-22. PubMed PMID: 7130852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of polyunsaturated fats on composition of plasma lipoproteins and apolipoproteins. AU - Vega,G L, AU - Groszek,E, AU - Wolf,R, AU - Grundy,S M, PY - 1982/8/1/pubmed PY - 1982/8/1/medline PY - 1982/8/1/entrez SP - 811 EP - 22 JF - Journal of lipid research JO - J Lipid Res VL - 23 IS - 6 N2 - The mechanisms of the hypocholesterolemic effect of polyunsaturated fats (PUSF) are not well understood. One possibility is that these fats uniquely reduce the cholesterol content of lipoproteins. The present study was carried out to determine specifically whether the ratio of cholesterol-to-protein (or apoB) in LDL (or other lipoproteins) is reduced by PUSF; also, lipoprotein composition was examined for other possible changes. Eight men and two women with different levels of plasma cholesterol were studied on the metabolic ward for 8 weeks. They were given a diet high in saturated fats (SF) for 4 weeks and another rich in PUSF for 4 weeks. On PUSF diets, mean plasma cholesterol decreased by 25% (SF = 296 +/- 27 (SEM) vs. PUSF = 223 +/- 21 mg/dl) as did total plasma apoB (155 +/- 8 vs. 116 +/- 13 mg/dl). LDL-Cholesterol decreased by 26%, and LDL-apoB fell by 29%. The mean ratio of cholesterol-to-apoB did not change significantly (SF = 1.52 +/- 0.04 vs. PUSF = 1.48 +/- 0.07). Likewise, HDL-cholesterol decreased by 15% (SF = 51 +/- 5 vs. PUSF = 43 +/- 4 mg/dl), and total plasma apoA-I was reduced by 19% (95 +/- 15 vs. 77 +/- 6 mg/dl); also, no change in the cholesterol-to-apoA-I in HDL was noted. Finally, there were no changes in cholesterol/apoB or triglyceride/apoB ratios in VLDL despite a 23% decrease in plasma triglycerides on PUSF. Thus, the hypocholesterolemic effect of PUSF was uniform for all lipoproteins and usually was accompanied by a corresponding decrease in concentrations of apoprotein constituents. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/7130852/Influence_of_polyunsaturated_fats_on_composition_of_plasma_lipoproteins_and_apolipoproteins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-2275(20)38083-4 DB - PRIME DP - Unbound Medicine ER -