Tags

Type your tag names separated by a space and hit enter

Masked megaloblastic anemia.
Arch Intern Med. 1982 Nov; 142(12):2111-4.AI

Abstract

In six patients, eight episodes of anemia associated with folic acid or vitamin B12 deficiency were unaccompanied by macrocytosis. Six of the eight episodes of anemia were complicated by illnesses of an inflammatory or infectious nature, two patients had iron deficiency, two appeared to have a thalassemia trait, and one had severe renal failure. In five of the eight episodes, erythropoiesis was not megaloblastic and there was insufficient anisocytosis or poikilocytosis to suggest an underlying vitamin deficiency state. Hypersegmented neutrophils were observed in all episodes, but a neutrophil lobe average of greater than 3.5 lobes per cell was observed only once, and in one patient, less than 5% of the circulating neutrophils were hypersegmented. Giant metamyelocytes, however, were present in the marrow in all of the episodes and provided an important clue to the presence of the vitamin deficiency state.

Authors

No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7138159

Citation

Spivak, J L.. "Masked Megaloblastic Anemia." Archives of Internal Medicine, vol. 142, no. 12, 1982, pp. 2111-4.
Spivak JL. Masked megaloblastic anemia. Arch Intern Med. 1982;142(12):2111-4.
Spivak, J. L. (1982). Masked megaloblastic anemia. Archives of Internal Medicine, 142(12), 2111-4.
Spivak JL. Masked Megaloblastic Anemia. Arch Intern Med. 1982;142(12):2111-4. PubMed PMID: 7138159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Masked megaloblastic anemia. A1 - Spivak,J L, PY - 1982/11/1/pubmed PY - 1982/11/1/medline PY - 1982/11/1/entrez SP - 2111 EP - 4 JF - Archives of internal medicine JO - Arch Intern Med VL - 142 IS - 12 N2 - In six patients, eight episodes of anemia associated with folic acid or vitamin B12 deficiency were unaccompanied by macrocytosis. Six of the eight episodes of anemia were complicated by illnesses of an inflammatory or infectious nature, two patients had iron deficiency, two appeared to have a thalassemia trait, and one had severe renal failure. In five of the eight episodes, erythropoiesis was not megaloblastic and there was insufficient anisocytosis or poikilocytosis to suggest an underlying vitamin deficiency state. Hypersegmented neutrophils were observed in all episodes, but a neutrophil lobe average of greater than 3.5 lobes per cell was observed only once, and in one patient, less than 5% of the circulating neutrophils were hypersegmented. Giant metamyelocytes, however, were present in the marrow in all of the episodes and provided an important clue to the presence of the vitamin deficiency state. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/7138159/Masked_megaloblastic_anemia_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/142/pg/2111 DB - PRIME DP - Unbound Medicine ER -