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Immunoglobulin levels, immunodeficiency and HLA in type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1982; 23(4):326-9D

Abstract

In 129 patients with Type 1 (insulin-dependent) diabetes mellitus, 100 healthy control subjects and 91 non-diabetic first degree relatives of Type 1 patients, we investigated variation in serum IgA, IgG and IgM concentrations with sex and HLA-B phenotype. Two patients with onset before the age of 15 years were completely IgA-deficient. One additional patient was completely IgG-deficient. Excluding these three cases, diabetic patients had serum IgA and IgM concentrations comparable to control subjects. IgG levels of patients were, however, significantly lower than those of control subjects (11.66 versus 12.69 g/l, p = 0.003). Non-diabetic first degree relatives of patients had IgG levels intermediate between those of diabetic patients and control subjects. There was some indication that IgA concentrations were lower in the 53 patients with HLA-B8 (1.91 versus 2.21 g/l, p = 0.038). No association was found between IgM or IgG levels and HLA phenotypes.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7141166

Citation

Hoddinott, S, et al. "Immunoglobulin Levels, Immunodeficiency and HLA in Type 1 (insulin-dependent) Diabetes Mellitus." Diabetologia, vol. 23, no. 4, 1982, pp. 326-9.
Hoddinott S, Dornan J, Bear JC, et al. Immunoglobulin levels, immunodeficiency and HLA in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1982;23(4):326-9.
Hoddinott, S., Dornan, J., Bear, J. C., & Farid, N. R. (1982). Immunoglobulin levels, immunodeficiency and HLA in type 1 (insulin-dependent) diabetes mellitus. Diabetologia, 23(4), pp. 326-9.
Hoddinott S, et al. Immunoglobulin Levels, Immunodeficiency and HLA in Type 1 (insulin-dependent) Diabetes Mellitus. Diabetologia. 1982;23(4):326-9. PubMed PMID: 7141166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin levels, immunodeficiency and HLA in type 1 (insulin-dependent) diabetes mellitus. AU - Hoddinott,S, AU - Dornan,J, AU - Bear,J C, AU - Farid,N R, PY - 1982/10/1/pubmed PY - 1982/10/1/medline PY - 1982/10/1/entrez SP - 326 EP - 9 JF - Diabetologia JO - Diabetologia VL - 23 IS - 4 N2 - In 129 patients with Type 1 (insulin-dependent) diabetes mellitus, 100 healthy control subjects and 91 non-diabetic first degree relatives of Type 1 patients, we investigated variation in serum IgA, IgG and IgM concentrations with sex and HLA-B phenotype. Two patients with onset before the age of 15 years were completely IgA-deficient. One additional patient was completely IgG-deficient. Excluding these three cases, diabetic patients had serum IgA and IgM concentrations comparable to control subjects. IgG levels of patients were, however, significantly lower than those of control subjects (11.66 versus 12.69 g/l, p = 0.003). Non-diabetic first degree relatives of patients had IgG levels intermediate between those of diabetic patients and control subjects. There was some indication that IgA concentrations were lower in the 53 patients with HLA-B8 (1.91 versus 2.21 g/l, p = 0.038). No association was found between IgM or IgG levels and HLA phenotypes. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/7141166/Immunoglobulin_levels_immunodeficiency_and_HLA_in_type_1__insulin_dependent__diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/8214 DB - PRIME DP - Unbound Medicine ER -