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[Regulation of the glyoxylic cycle: effect of the NADPH/NADP ratio].
Rev Esp Fisiol. 1982; 38 Suppl:141-6.RE

Abstract

The utilization of two-carbon sources is carried out through the operation of the glyoxylic acid cycle. The cycle involves several Krebs cycle steps as well as two additional specific enzymes, isocitrate lyase and malate synthase. Kinetic data from the isocitrate transforming enzymes suggest that the flow of isocitrate through the glyoxylic acid cycle depends upon the inhibition of the isocitrate decarboxylating enzymes. Three different mechanisms have been proposed at present that could account for this inhibition: a) Inhibition by concerted action of oxalacetate and glyoxylate; b) NADP-linked isocitrate dehydrogenase phosphorilation in E. coli, and c) competitive inhibition by NADPH with respect to NADP. In the present case the variations of the NADPH/NADP ratio would be channeling the utilization of isocitrate into the glyoxylic acid cycle.

Authors

No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

7146569

Citation

Machado, A. "[Regulation of the Glyoxylic Cycle: Effect of the NADPH/NADP Ratio]." Revista Espanola De Fisiologia, vol. 38 Suppl, 1982, pp. 141-6.
Machado A. [Regulation of the glyoxylic cycle: effect of the NADPH/NADP ratio]. Rev Esp Fisiol. 1982;38 Suppl:141-6.
Machado, A. (1982). [Regulation of the glyoxylic cycle: effect of the NADPH/NADP ratio]. Revista Espanola De Fisiologia, 38 Suppl, 141-6.
Machado A. [Regulation of the Glyoxylic Cycle: Effect of the NADPH/NADP Ratio]. Rev Esp Fisiol. 1982;38 Suppl:141-6. PubMed PMID: 7146569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Regulation of the glyoxylic cycle: effect of the NADPH/NADP ratio]. A1 - Machado,A, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 141 EP - 6 JF - Revista espanola de fisiologia JO - Rev Esp Fisiol VL - 38 Suppl N2 - The utilization of two-carbon sources is carried out through the operation of the glyoxylic acid cycle. The cycle involves several Krebs cycle steps as well as two additional specific enzymes, isocitrate lyase and malate synthase. Kinetic data from the isocitrate transforming enzymes suggest that the flow of isocitrate through the glyoxylic acid cycle depends upon the inhibition of the isocitrate decarboxylating enzymes. Three different mechanisms have been proposed at present that could account for this inhibition: a) Inhibition by concerted action of oxalacetate and glyoxylate; b) NADP-linked isocitrate dehydrogenase phosphorilation in E. coli, and c) competitive inhibition by NADPH with respect to NADP. In the present case the variations of the NADPH/NADP ratio would be channeling the utilization of isocitrate into the glyoxylic acid cycle. SN - 0034-9402 UR - https://www.unboundmedicine.com/medline/citation/7146569/[Regulation_of_the_glyoxylic_cycle:_effect_of_the_NADPH/NADP_ratio]_ DB - PRIME DP - Unbound Medicine ER -