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The irreversibly sickled cell.
Am J Pediatr Hematol Oncol. 1982 Fall; 4(3):307-15.AJ

Abstract

The characteristics of irreversibly sickled cells (ISC) are reviewed in relationship to their potential significance in the initiation of sickle cell vaso-occlusion. Although ISC are implicated in the shortened red cell survival of sickle cell anemia, there is no direct correlation to the frequency or severity of sickle crisis. ISC are heterogeneous in their physical properties suggesting the possibility that a subpopulation may be disproportionately important in causing vaso-occlusion. Study of their deformability heterogeneity of ISC showed that filtration-separated hard ISC are similar in morphology and intracellular composition to soft ISC, and would not be distinguished on blood smear.

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Authors

Smith CM
No affiliation info available
Krivit W
No affiliation info available
White JG
No affiliation info available

MeSH

Anemia, Sickle CellErythrocyte AgingErythrocyte MembraneErythrocytes, AbnormalHumansMicroscopy, Electron, Scanning

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7149169

Citation

Smith, C M., et al. "The Irreversibly Sickled Cell." The American Journal of Pediatric Hematology/oncology, vol. 4, no. 3, 1982, pp. 307-15.
Smith CM, Krivit W, White JG. The irreversibly sickled cell. Am J Pediatr Hematol Oncol. 1982;4(3):307-15.
Smith, C. M., Krivit, W., & White, J. G. (1982). The irreversibly sickled cell. The American Journal of Pediatric Hematology/oncology, 4(3), 307-15.
Smith CM, Krivit W, White JG. The Irreversibly Sickled Cell. Am J Pediatr Hematol Oncol. 1982;4(3):307-15. PubMed PMID: 7149169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The irreversibly sickled cell. AU - Smith,C M,2nd AU - Krivit,W, AU - White,J G, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 307 EP - 15 JF - The American journal of pediatric hematology/oncology JO - Am J Pediatr Hematol Oncol VL - 4 IS - 3 N2 - The characteristics of irreversibly sickled cells (ISC) are reviewed in relationship to their potential significance in the initiation of sickle cell vaso-occlusion. Although ISC are implicated in the shortened red cell survival of sickle cell anemia, there is no direct correlation to the frequency or severity of sickle crisis. ISC are heterogeneous in their physical properties suggesting the possibility that a subpopulation may be disproportionately important in causing vaso-occlusion. Study of their deformability heterogeneity of ISC showed that filtration-separated hard ISC are similar in morphology and intracellular composition to soft ISC, and would not be distinguished on blood smear. SN - 0192-8562 UR - https://www.unboundmedicine.com/medline/citation/7149169/The_irreversibly_sickled_cell_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7149169.ui DB - PRIME DP - Unbound Medicine ER -