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Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway caliber.
Am Rev Respir Dis. 1982 Nov; 126(5):849-54.AR

Abstract

We examined the effects of pharmacologic antagonists on the bronchial response to inhaled histamine in 11 normal and 11 asthmatic subjects. We constructed cumulative log dose-response curves and determined the steepest slope and the provocative dose of histamine (PD35) needed to cause a 35% fall in specific airway conductance (SGaw). The slope was positively related to starting SGaw in both groups. Starting SGaw and slope were approximately 2-fold lower in asthmatics. After inhaling salbutamol (200 micrograms) and atropine (4 mg), there was an increase in starting SGaw and slope of the histamine response by approximately 1.5-fold in normal subjects and 2-fold in asthmatics, the relationship between starting SGaw and slope being preserved. Chlorpheniramine (4 mg) had little effect on starting SGaw and slope.l Atropine, salibutamol, and chlorpheniramine increased PD35 by approximately 4-fold in normal subjects and 6-fold in asthmatics. Afte bronchodilatation with atropine or salbutamol, mean starting SGaw, slope, and PD35 of the responses in asthmatics were similar to those of unpremedicated normal subjects. Thus, the slope of the histamine dose-response curve is largely determined by the starting airway caliber, increases in PD35 by drugs reflect in part the effects of bronchodilatation and in part their specific pharmacologic antagonist activity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7149450

Citation

Chung, K F., et al. "Histamine Dose-response Relationships in Normal and Asthmatic Subjects. the Importance of Starting Airway Caliber." The American Review of Respiratory Disease, vol. 126, no. 5, 1982, pp. 849-54.
Chung KF, Morgan B, Keyes SJ, et al. Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway caliber. Am Rev Respir Dis. 1982;126(5):849-54.
Chung, K. F., Morgan, B., Keyes, S. J., & Snashall, P. D. (1982). Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway caliber. The American Review of Respiratory Disease, 126(5), 849-54.
Chung KF, et al. Histamine Dose-response Relationships in Normal and Asthmatic Subjects. the Importance of Starting Airway Caliber. Am Rev Respir Dis. 1982;126(5):849-54. PubMed PMID: 7149450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway caliber. AU - Chung,K F, AU - Morgan,B, AU - Keyes,S J, AU - Snashall,P D, PY - 1982/11/1/pubmed PY - 1982/11/1/medline PY - 1982/11/1/entrez SP - 849 EP - 54 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 126 IS - 5 N2 - We examined the effects of pharmacologic antagonists on the bronchial response to inhaled histamine in 11 normal and 11 asthmatic subjects. We constructed cumulative log dose-response curves and determined the steepest slope and the provocative dose of histamine (PD35) needed to cause a 35% fall in specific airway conductance (SGaw). The slope was positively related to starting SGaw in both groups. Starting SGaw and slope were approximately 2-fold lower in asthmatics. After inhaling salbutamol (200 micrograms) and atropine (4 mg), there was an increase in starting SGaw and slope of the histamine response by approximately 1.5-fold in normal subjects and 2-fold in asthmatics, the relationship between starting SGaw and slope being preserved. Chlorpheniramine (4 mg) had little effect on starting SGaw and slope.l Atropine, salibutamol, and chlorpheniramine increased PD35 by approximately 4-fold in normal subjects and 6-fold in asthmatics. Afte bronchodilatation with atropine or salbutamol, mean starting SGaw, slope, and PD35 of the responses in asthmatics were similar to those of unpremedicated normal subjects. Thus, the slope of the histamine dose-response curve is largely determined by the starting airway caliber, increases in PD35 by drugs reflect in part the effects of bronchodilatation and in part their specific pharmacologic antagonist activity. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/7149450/Histamine_dose_response_relationships_in_normal_and_asthmatic_subjects__The_importance_of_starting_airway_caliber_ L2 - https://www.atsjournals.org/doi/10.1164/arrd.1982.126.5.849?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -