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Health effects among newborns after prenatal exposure to ClO2-disinfected drinking water.
Environ Health Perspect. 1982 Dec; 46:39-45.EH

Abstract

Because chlorination of potable surface waters may be associated with increased risk of carcinogenicity, substitute methods for the routine disinfection of public water supplies are being explored. As part of this search, it is especially important that the potential health effects of each alternative method should be considered. Chemical treatment of drinking water by chlorine dioxide (ClO2) is a likely alternative mode of disinfection. Two common by-products of the ClO2 disinfection of surface water are chlorate and chlorite. These oxidants may have negative health effects on certain high risk groups. Newborns, in particular, would seem to be at increased risk to red cell damage from oxidant stress. The historical record study being reported here compares the morbidity and mortality experience of newborns in two similar communities, one of which used chlorination and the other which used high levels of chlorine dioxide for potable water disinfection. A statistically significant positive association was found between exposure of the mother to ClO2-treated water during pregnancy and prematurity of the newborn as assessed by the attending physician and by a greater weight loss after birth. The rates of jaundice, birth defects and fetal and neonatal mortality did not differ significantly between communities. Because of the limitations of the study design, the findings reported here should be considered suggestive rather than definitive.

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Authors

Tuthill RW
No affiliation info available
Giusti RA
No affiliation info available
Moore GS
No affiliation info available
Calabrese EJ
No affiliation info available

MeSH

AdolescentAdultBirth WeightChlorineChlorine CompoundsDisinfectantsFemaleHealthHealth StatusHumansInfant MortalityInfant, NewbornMassachusettsMaternal-Fetal ExchangeOxidesPregnancyPrenatal Exposure Delayed EffectsWater Supply

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7151766

Citation

Tuthill, R W., et al. "Health Effects Among Newborns After Prenatal Exposure to ClO2-disinfected Drinking Water." Environmental Health Perspectives, vol. 46, 1982, pp. 39-45.
Tuthill RW, Giusti RA, Moore GS, et al. Health effects among newborns after prenatal exposure to ClO2-disinfected drinking water. Environ Health Perspect. 1982;46:39-45.
Tuthill, R. W., Giusti, R. A., Moore, G. S., & Calabrese, E. J. (1982). Health effects among newborns after prenatal exposure to ClO2-disinfected drinking water. Environmental Health Perspectives, 46, 39-45.
Tuthill RW, et al. Health Effects Among Newborns After Prenatal Exposure to ClO2-disinfected Drinking Water. Environ Health Perspect. 1982;46:39-45. PubMed PMID: 7151766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health effects among newborns after prenatal exposure to ClO2-disinfected drinking water. AU - Tuthill,R W, AU - Giusti,R A, AU - Moore,G S, AU - Calabrese,E J, PY - 1982/12/1/pubmed PY - 1982/12/1/medline PY - 1982/12/1/entrez SP - 39 EP - 45 JF - Environmental health perspectives JO - Environ Health Perspect VL - 46 N2 - Because chlorination of potable surface waters may be associated with increased risk of carcinogenicity, substitute methods for the routine disinfection of public water supplies are being explored. As part of this search, it is especially important that the potential health effects of each alternative method should be considered. Chemical treatment of drinking water by chlorine dioxide (ClO2) is a likely alternative mode of disinfection. Two common by-products of the ClO2 disinfection of surface water are chlorate and chlorite. These oxidants may have negative health effects on certain high risk groups. Newborns, in particular, would seem to be at increased risk to red cell damage from oxidant stress. The historical record study being reported here compares the morbidity and mortality experience of newborns in two similar communities, one of which used chlorination and the other which used high levels of chlorine dioxide for potable water disinfection. A statistically significant positive association was found between exposure of the mother to ClO2-treated water during pregnancy and prematurity of the newborn as assessed by the attending physician and by a greater weight loss after birth. The rates of jaundice, birth defects and fetal and neonatal mortality did not differ significantly between communities. Because of the limitations of the study design, the findings reported here should be considered suggestive rather than definitive. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/7151766/Health_effects_among_newborns_after_prenatal_exposure_to_ClO2_disinfected_drinking_water_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.824639?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -