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Oral contraceptives and breast cancer.

Abstract

A case-control interview study, conducted among participants in the Breast Cancer Detection Demonstration Project and involving 963 breast cancer cases and 858 controls, allowed evaluation of the risk of breast cancer associated with use of oral contraceptives. Overall, there was no association between use and risk of disease (RR = 1.1). In addition, there was no indication of increasing risk with years of use or years since initial use, despite slight excess risks observed among users of high-dose preparations. Premenopausal women who used the pill after the age of 40 demonstrated approximately a 50% increased risk, possibly as a result of artificial prolongation of a premenopausal rate of disease incidence. Non-significant excess risks associated with pill use were also seen among premenopausal women who reported a family history of breast cancer in a sister (RR = 3.6) or previous biopsies for benign breast disease (RR = 3.2). The latter excess was limited to women whose use of the pill preceded a first biopsy, suggesting that the types of lesions requiring biopsy among current long-term pill users may be those that predispose to breast cancer.

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  • Authors

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    MeSH

    Adult
    Breast Neoplasms
    Contraceptives, Oral
    Contraceptives, Oral, Hormonal
    Epidemiologic Methods
    Estradiol Congeners
    Female
    Humans
    Menopause
    Middle Aged
    Risk

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    7152784

    Citation

    Brinton, L A., et al. "Oral Contraceptives and Breast Cancer." International Journal of Epidemiology, vol. 11, no. 4, 1982, pp. 316-22.
    Brinton LA, Hoover R, Szklo M, et al. Oral contraceptives and breast cancer. Int J Epidemiol. 1982;11(4):316-22.
    Brinton, L. A., Hoover, R., Szklo, M., & Fraumeni, J. F. (1982). Oral contraceptives and breast cancer. International Journal of Epidemiology, 11(4), pp. 316-22.
    Brinton LA, et al. Oral Contraceptives and Breast Cancer. Int J Epidemiol. 1982;11(4):316-22. PubMed PMID: 7152784.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oral contraceptives and breast cancer. AU - Brinton,L A, AU - Hoover,R, AU - Szklo,M, AU - Fraumeni,J F,Jr PY - 1982/12/1/pubmed PY - 2001/3/28/medline PY - 1982/12/1/entrez KW - Age Factors KW - Americas KW - Breast Cancer KW - Cancer KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Family Planning KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives--side effects KW - Population KW - Population Characteristics KW - Reproductive Control Agents KW - Research Methodology KW - Studies KW - United States SP - 316 EP - 22 JF - International journal of epidemiology JO - Int J Epidemiol VL - 11 IS - 4 N2 - A case-control interview study, conducted among participants in the Breast Cancer Detection Demonstration Project and involving 963 breast cancer cases and 858 controls, allowed evaluation of the risk of breast cancer associated with use of oral contraceptives. Overall, there was no association between use and risk of disease (RR = 1.1). In addition, there was no indication of increasing risk with years of use or years since initial use, despite slight excess risks observed among users of high-dose preparations. Premenopausal women who used the pill after the age of 40 demonstrated approximately a 50% increased risk, possibly as a result of artificial prolongation of a premenopausal rate of disease incidence. Non-significant excess risks associated with pill use were also seen among premenopausal women who reported a family history of breast cancer in a sister (RR = 3.6) or previous biopsies for benign breast disease (RR = 3.2). The latter excess was limited to women whose use of the pill preceded a first biopsy, suggesting that the types of lesions requiring biopsy among current long-term pill users may be those that predispose to breast cancer. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/7152784/Oral_contraceptives_and_breast_cancer_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/11.4.316 DB - PRIME DP - Unbound Medicine ER -