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Subacute sclerosing panencephalitis. An autopsy case with impaired cellular immunity.
Acta Pathol Jpn. 1982 Nov; 32(6):1103-10.AP

Abstract

An autopsy case of subacute sclerosing panencephalitis (SSPE) in a 5-year-old boy, with rapid progression to a comatose state in 2 weeks after the onset of right hemiplegia, is described. The levels of antibody to measles virus in the serum and the cerebrospinal fluid were increased, and high levels of IgG in the latter were found. A characteristic pattern of electroencephalogram (EEG) showing periodic suppression of high voltage complexes was also found during the course of the disease. Microscopical examination revealed perivascular cuffing, numerous hypertrophied astrocytes with a diffuse gliosis and sporadic intranuclear inclusions in the brain. In addition to these typical findings of SSPE, impaired cellular immunity was recognized by delayed skin test in vivo, and pathologically severe atrophy of thymus, and follicular atrophy of spleen with amyloid deposition in the wall of the sheathed arteries were found.

Authors

Ueda K
No affiliation info available
Imamura T
No affiliation info available
Kawaguchi T
No affiliation info available
Tamari H
No affiliation info available
Kambara T
No affiliation info available

MeSH

Antibodies, ViralBrainChild, PreschoolHumansImmunity, CellularImmunoglobulinsLymphocyte ActivationMaleMeasles virusSubacute Sclerosing Panencephalitis

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

7158343

Citation

Ueda, K, et al. "Subacute Sclerosing Panencephalitis. an Autopsy Case With Impaired Cellular Immunity." Acta Pathologica Japonica, vol. 32, no. 6, 1982, pp. 1103-10.
Ueda K, Imamura T, Kawaguchi T, et al. Subacute sclerosing panencephalitis. An autopsy case with impaired cellular immunity. Acta Pathol Jpn. 1982;32(6):1103-10.
Ueda, K., Imamura, T., Kawaguchi, T., Tamari, H., & Kambara, T. (1982). Subacute sclerosing panencephalitis. An autopsy case with impaired cellular immunity. Acta Pathologica Japonica, 32(6), 1103-10.
Ueda K, et al. Subacute Sclerosing Panencephalitis. an Autopsy Case With Impaired Cellular Immunity. Acta Pathol Jpn. 1982;32(6):1103-10. PubMed PMID: 7158343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subacute sclerosing panencephalitis. An autopsy case with impaired cellular immunity. AU - Ueda,K, AU - Imamura,T, AU - Kawaguchi,T, AU - Tamari,H, AU - Kambara,T, PY - 1982/11/1/pubmed PY - 1982/11/1/medline PY - 1982/11/1/entrez SP - 1103 EP - 10 JF - Acta pathologica japonica JO - Acta Pathol Jpn VL - 32 IS - 6 N2 - An autopsy case of subacute sclerosing panencephalitis (SSPE) in a 5-year-old boy, with rapid progression to a comatose state in 2 weeks after the onset of right hemiplegia, is described. The levels of antibody to measles virus in the serum and the cerebrospinal fluid were increased, and high levels of IgG in the latter were found. A characteristic pattern of electroencephalogram (EEG) showing periodic suppression of high voltage complexes was also found during the course of the disease. Microscopical examination revealed perivascular cuffing, numerous hypertrophied astrocytes with a diffuse gliosis and sporadic intranuclear inclusions in the brain. In addition to these typical findings of SSPE, impaired cellular immunity was recognized by delayed skin test in vivo, and pathologically severe atrophy of thymus, and follicular atrophy of spleen with amyloid deposition in the wall of the sheathed arteries were found. SN - 0001-6632 UR - https://www.unboundmedicine.com/medline/citation/7158343/Subacute_sclerosing_panencephalitis__An_autopsy_case_with_impaired_cellular_immunity_ L2 - http://www.diseaseinfosearch.org/result/6907 DB - PRIME DP - Unbound Medicine ER -