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Effects of cetiedil on monovalent cation permeability in the erythrocyte: an explanation for the efficacy of cetiedil in the treatment of sickle cell anemia.
Blood Cells. 1982; 8(2):283-8.BC

Abstract

Cetiedil, a drug reported to relieve painful crises in sickle cell anemia, has direct antisickling properties in vitro. However, neither oxygen affinity nor the solubility of deoxyhemoglobin S is altered by cetiedil. Due to the great influence the concentration of hemoglobin S has on the kinetics of gelation, we hypothesized that cetiedil might inhibit sickling by modifying erythrocyte Na+ or K+ movements in a manner which would prevent a rise in the concentration of intracellular hemoglobin. Cetiedil has two such effects: It causes a rise in passive Na+ movements and it inhibits a specific increase in K+ permeability secondary to a rise in cytoplasmic Ca2+ concentration. Cetiedil then may represent an alternate type of antisickling agent, exerting its effect through changes in erythrocyte membrane cation permeability rather than directly modifying hemoglobin S.

Authors

Berkowitz LR
No affiliation info available
Orringer EP
No affiliation info available

MeSH

Anemia, Sickle CellAntisickling AgentsAzepinesCations, MonovalentCell Membrane PermeabilityErythrocytes, AbnormalHumansOxygenSodium

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7159752

Citation

Berkowitz, L R., and E P. Orringer. "Effects of Cetiedil On Monovalent Cation Permeability in the Erythrocyte: an Explanation for the Efficacy of Cetiedil in the Treatment of Sickle Cell Anemia." Blood Cells, vol. 8, no. 2, 1982, pp. 283-8.
Berkowitz LR, Orringer EP. Effects of cetiedil on monovalent cation permeability in the erythrocyte: an explanation for the efficacy of cetiedil in the treatment of sickle cell anemia. Blood Cells. 1982;8(2):283-8.
Berkowitz, L. R., & Orringer, E. P. (1982). Effects of cetiedil on monovalent cation permeability in the erythrocyte: an explanation for the efficacy of cetiedil in the treatment of sickle cell anemia. Blood Cells, 8(2), 283-8.
Berkowitz LR, Orringer EP. Effects of Cetiedil On Monovalent Cation Permeability in the Erythrocyte: an Explanation for the Efficacy of Cetiedil in the Treatment of Sickle Cell Anemia. Blood Cells. 1982;8(2):283-8. PubMed PMID: 7159752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cetiedil on monovalent cation permeability in the erythrocyte: an explanation for the efficacy of cetiedil in the treatment of sickle cell anemia. AU - Berkowitz,L R, AU - Orringer,E P, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 283 EP - 8 JF - Blood cells JO - Blood Cells VL - 8 IS - 2 N2 - Cetiedil, a drug reported to relieve painful crises in sickle cell anemia, has direct antisickling properties in vitro. However, neither oxygen affinity nor the solubility of deoxyhemoglobin S is altered by cetiedil. Due to the great influence the concentration of hemoglobin S has on the kinetics of gelation, we hypothesized that cetiedil might inhibit sickling by modifying erythrocyte Na+ or K+ movements in a manner which would prevent a rise in the concentration of intracellular hemoglobin. Cetiedil has two such effects: It causes a rise in passive Na+ movements and it inhibits a specific increase in K+ permeability secondary to a rise in cytoplasmic Ca2+ concentration. Cetiedil then may represent an alternate type of antisickling agent, exerting its effect through changes in erythrocyte membrane cation permeability rather than directly modifying hemoglobin S. SN - 0340-4684 UR - https://www.unboundmedicine.com/medline/citation/7159752/Effects_of_cetiedil_on_monovalent_cation_permeability_in_the_erythrocyte:_an_explanation_for_the_efficacy_of_cetiedil_in_the_treatment_of_sickle_cell_anemia_ L2 - http://babysfirsttest.org/newborn-screening/conditions/sickle-cell-anemia DB - PRIME DP - Unbound Medicine ER -