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The treatment of sickle cell anemia with induced hyponatremia.
Blood Cells. 1982; 8(2):329-35.BC

Abstract

Since the rate of polymerization of sickle hemoglobin is exquisitely dependent on its concentration, a small reduction in intracellular hemoglobin concentration should cause a significant inhibition of sickling. In three patients with homozygous sickle cell anemia, sustained hyponatremia was induced by a program consisting of a high fluid intake, a low salt diet and a vasopressin analog, DDAVP. During periods of hyponatremia, mean corpuscular hemoglobin concentration (MCHC) fell 13% and in vitro sickling was reduced as assessed by morphology and oxygen affinity. The frequency and duration of sickle cell crises appeared to be decreased during periods when patients were hyponatremic. These preliminary results indicate that reduction in intracellular hemoglobin concentration is an effective approach to the treatment of sickle cell anemia.

Authors

Rosa RM
No affiliation info available
Bierer BE
No affiliation info available
Bunn HF
No affiliation info available
Epstein FH
No affiliation info available

MeSH

Anemia, Sickle CellDeamino Arginine VasopressinDiet, Sodium-RestrictedErythrocyte IndicesErythrocytes, AbnormalHemoglobin, SickleHumansHyponatremiaOxygenSodiumWater-Electrolyte Balance

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7159756

Citation

Rosa, R M., et al. "The Treatment of Sickle Cell Anemia With Induced Hyponatremia." Blood Cells, vol. 8, no. 2, 1982, pp. 329-35.
Rosa RM, Bierer BE, Bunn HF, et al. The treatment of sickle cell anemia with induced hyponatremia. Blood Cells. 1982;8(2):329-35.
Rosa, R. M., Bierer, B. E., Bunn, H. F., & Epstein, F. H. (1982). The treatment of sickle cell anemia with induced hyponatremia. Blood Cells, 8(2), 329-35.
Rosa RM, et al. The Treatment of Sickle Cell Anemia With Induced Hyponatremia. Blood Cells. 1982;8(2):329-35. PubMed PMID: 7159756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The treatment of sickle cell anemia with induced hyponatremia. AU - Rosa,R M, AU - Bierer,B E, AU - Bunn,H F, AU - Epstein,F H, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 329 EP - 35 JF - Blood cells JO - Blood Cells VL - 8 IS - 2 N2 - Since the rate of polymerization of sickle hemoglobin is exquisitely dependent on its concentration, a small reduction in intracellular hemoglobin concentration should cause a significant inhibition of sickling. In three patients with homozygous sickle cell anemia, sustained hyponatremia was induced by a program consisting of a high fluid intake, a low salt diet and a vasopressin analog, DDAVP. During periods of hyponatremia, mean corpuscular hemoglobin concentration (MCHC) fell 13% and in vitro sickling was reduced as assessed by morphology and oxygen affinity. The frequency and duration of sickle cell crises appeared to be decreased during periods when patients were hyponatremic. These preliminary results indicate that reduction in intracellular hemoglobin concentration is an effective approach to the treatment of sickle cell anemia. SN - 0340-4684 UR - https://www.unboundmedicine.com/medline/citation/7159756/The_treatment_of_sickle_cell_anemia_with_induced_hyponatremia_ L2 - http://babysfirsttest.org/newborn-screening/conditions/sickle-cell-anemia DB - PRIME DP - Unbound Medicine ER -