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Glycemic control in pregnant diabetic women using a continuous subcutaneous insulin infusion pump.
J Reprod Med. 1982 Oct; 27(10):651-4.JR

Abstract

Five insulin-dependent diabetics in the third trimester of pregnancy were first stabilized on morning and evening injections of both short- and long-acting insulin. Blood sugars were determined hourly from 7 A.M. to 7 P.M. and then every two hours from 7 P.M. to 7 A.M. After glycemic control was established, the patients were treated with continuous subcutaneous insulin infusion via a pump that administers a basal dosage at predetermined intervals and bolus doses preprandially. Mean blood sugar, glycemic excursions and intervals of hypoglycemia and hyperglycemia were calculated after three to five days of infusion therapy. The continuous subcutaneous insulin infusion with the pump did not improve glycemic control in the group as a whole, but in two of five patients there was a significant decrease in mean blood sugar. A trend towards a decrease in glycemic excursions as well as hypoglycemia and hyperglycemia was also obtained. Three patients were managed with long-term home and in-hospital use of the continuous subcutaneous insulin infusion pump. It proved to be efficacious and safe in establishing euglycemia. This study of a portable insulin infusion pump affirms its ability to maintain glycemic control and its safety for long-term therapy during pregnancy.

Authors

Cohen AW
No affiliation info available
Liston RM
No affiliation info available
Mennuti MT
No affiliation info available
Gabbe SG
No affiliation info available

MeSH

Diabetes MellitusEvaluation Studies as TopicFemaleHumansInsulin Infusion SystemsPregnancyPregnancy in Diabetics

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7175835

Citation

Cohen, A W., et al. "Glycemic Control in Pregnant Diabetic Women Using a Continuous Subcutaneous Insulin Infusion Pump." The Journal of Reproductive Medicine, vol. 27, no. 10, 1982, pp. 651-4.
Cohen AW, Liston RM, Mennuti MT, et al. Glycemic control in pregnant diabetic women using a continuous subcutaneous insulin infusion pump. J Reprod Med. 1982;27(10):651-4.
Cohen, A. W., Liston, R. M., Mennuti, M. T., & Gabbe, S. G. (1982). Glycemic control in pregnant diabetic women using a continuous subcutaneous insulin infusion pump. The Journal of Reproductive Medicine, 27(10), 651-4.
Cohen AW, et al. Glycemic Control in Pregnant Diabetic Women Using a Continuous Subcutaneous Insulin Infusion Pump. J Reprod Med. 1982;27(10):651-4. PubMed PMID: 7175835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycemic control in pregnant diabetic women using a continuous subcutaneous insulin infusion pump. AU - Cohen,A W, AU - Liston,R M, AU - Mennuti,M T, AU - Gabbe,S G, PY - 1982/10/1/pubmed PY - 1982/10/1/medline PY - 1982/10/1/entrez SP - 651 EP - 4 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 27 IS - 10 N2 - Five insulin-dependent diabetics in the third trimester of pregnancy were first stabilized on morning and evening injections of both short- and long-acting insulin. Blood sugars were determined hourly from 7 A.M. to 7 P.M. and then every two hours from 7 P.M. to 7 A.M. After glycemic control was established, the patients were treated with continuous subcutaneous insulin infusion via a pump that administers a basal dosage at predetermined intervals and bolus doses preprandially. Mean blood sugar, glycemic excursions and intervals of hypoglycemia and hyperglycemia were calculated after three to five days of infusion therapy. The continuous subcutaneous insulin infusion with the pump did not improve glycemic control in the group as a whole, but in two of five patients there was a significant decrease in mean blood sugar. A trend towards a decrease in glycemic excursions as well as hypoglycemia and hyperglycemia was also obtained. Three patients were managed with long-term home and in-hospital use of the continuous subcutaneous insulin infusion pump. It proved to be efficacious and safe in establishing euglycemia. This study of a portable insulin infusion pump affirms its ability to maintain glycemic control and its safety for long-term therapy during pregnancy. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/7175835/Glycemic_control_in_pregnant_diabetic_women_using_a_continuous_subcutaneous_insulin_infusion_pump_ DB - PRIME DP - Unbound Medicine ER -