Tags

Type your tag names separated by a space and hit enter

[Volumetric correction of the maximal expiratory flow 25-75% in chronic obstructive bronchopneumopathies].
Rev Fr Mal Respir. 1982; 10(5):337-44.RF

Abstract

After inhalation of a bronchodilator aerosol, indices of airway obstruction usually improve whereas the forced expiratory flow between 25 and 75% (FEF25-75%) of the forced vital capacity (FVC) commonly remains the same or may decrease. This is due to the fact that the FEF25-75% after bronchodilatation is measured at lower absolute lung volumes with subsequently less elastic recoil pressure. A goal of this study was to analyze this test after volume adjusting so that the flows before and after a bronchodilator are compared at equal volumes (isovolume). Thirty-seven men with chronic obstructive pulmonary disease (COPD) performed maximal forced expiratory maneuvers before and 15 minutes after isoproterenol (0.15 mg) inhalation. The mean value of isovolume (0.56 +/- .30 1. sec-1) was significantly greater (p less than 0.001) than the FEF25-75% recorded before (0.45 +/- .26 1. sec-1) and after (0.50 +/- .27 1. sec-1, p less than 0.01) bronchodilator inhalation. The FVC was improved in 18 patients but only 6 (33%) had an improved conventional FEF25-75%. On the other hand, isovolume FEF improved in 12 (66%) patients. Isovolume FEF also improved twice as frequently as conventional FEF25-75% in those demonstrating an improvement in forced expiratory volume in the first second (FEV1). Furthermore, when the conventional FEF25-75% demonstrated no improvement after isoproterenol inhalation, isovolume improved in 8/26 (31%) of these patients. Our results suggest that volume adjusting the FEF25-75% after isoproterenol inhalation increases its sensitivity for detecting acute bronchodilation in patients with COPD, and that this methods appears practical in routine pulmonary function testing.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

fre

PubMed ID

7178638

Citation

Dull, W L., et al. "[Volumetric Correction of the Maximal Expiratory Flow 25-75% in Chronic Obstructive Bronchopneumopathies]." Revue Francaise Des Maladies Respiratoires, vol. 10, no. 5, 1982, pp. 337-44.
Dull WL, Alexander MR, Kasik JE. [Volumetric correction of the maximal expiratory flow 25-75% in chronic obstructive bronchopneumopathies]. Rev Fr Mal Respir. 1982;10(5):337-44.
Dull, W. L., Alexander, M. R., & Kasik, J. E. (1982). [Volumetric correction of the maximal expiratory flow 25-75% in chronic obstructive bronchopneumopathies]. Revue Francaise Des Maladies Respiratoires, 10(5), 337-44.
Dull WL, Alexander MR, Kasik JE. [Volumetric Correction of the Maximal Expiratory Flow 25-75% in Chronic Obstructive Bronchopneumopathies]. Rev Fr Mal Respir. 1982;10(5):337-44. PubMed PMID: 7178638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Volumetric correction of the maximal expiratory flow 25-75% in chronic obstructive bronchopneumopathies]. AU - Dull,W L, AU - Alexander,M R, AU - Kasik,J E, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 337 EP - 44 JF - Revue francaise des maladies respiratoires JO - Rev Fr Mal Respir VL - 10 IS - 5 N2 - After inhalation of a bronchodilator aerosol, indices of airway obstruction usually improve whereas the forced expiratory flow between 25 and 75% (FEF25-75%) of the forced vital capacity (FVC) commonly remains the same or may decrease. This is due to the fact that the FEF25-75% after bronchodilatation is measured at lower absolute lung volumes with subsequently less elastic recoil pressure. A goal of this study was to analyze this test after volume adjusting so that the flows before and after a bronchodilator are compared at equal volumes (isovolume). Thirty-seven men with chronic obstructive pulmonary disease (COPD) performed maximal forced expiratory maneuvers before and 15 minutes after isoproterenol (0.15 mg) inhalation. The mean value of isovolume (0.56 +/- .30 1. sec-1) was significantly greater (p less than 0.001) than the FEF25-75% recorded before (0.45 +/- .26 1. sec-1) and after (0.50 +/- .27 1. sec-1, p less than 0.01) bronchodilator inhalation. The FVC was improved in 18 patients but only 6 (33%) had an improved conventional FEF25-75%. On the other hand, isovolume FEF improved in 12 (66%) patients. Isovolume FEF also improved twice as frequently as conventional FEF25-75% in those demonstrating an improvement in forced expiratory volume in the first second (FEV1). Furthermore, when the conventional FEF25-75% demonstrated no improvement after isoproterenol inhalation, isovolume improved in 8/26 (31%) of these patients. Our results suggest that volume adjusting the FEF25-75% after isoproterenol inhalation increases its sensitivity for detecting acute bronchodilation in patients with COPD, and that this methods appears practical in routine pulmonary function testing. SN - 0301-0279 UR - https://www.unboundmedicine.com/medline/citation/7178638/[Volumetric_correction_of_the_maximal_expiratory_flow_25_75_in_chronic_obstructive_bronchopneumopathies]_ DB - PRIME DP - Unbound Medicine ER -