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The possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people.
Acta Med Acad Sci Hung. 1982; 39(1-2):11-7.AM

Abstract

Healthy subjects aged 70-90 and 20-40 years were investigated for the level of reverse triiodothyronine (rT3). The mean level in 57 old subjects was higher and the triiodothyronine (T3) level lower than in 30 young persons. No negative correlation was observed. A serum T3 elevation caused by liothyronine administration (5-15 micrograms/day for two weeks) was not followed by a change of the mean rT3 level in 12 old subjects. After a single intramuscular thyrotropin (TSH) injection, the rT3 elevation lasted 24h longer in 19 old persons than in the 9 control ones, though the early rT3 response was similar in both groups. Propranolol administration (40 mg t.i.d. for a week) caused a similar rT3 elevation in old persons (n = 18) as in 12 young ones. From the indirect data it is concluded that the serum rT3 elevation in old age is a result of faster peripheral generation and not of increased production in the thyroid gland. The data do not indicate any change of rT3 metabolism. T4-T3 and T4-rT3 conversion are provoked by different enzymes. The elevation of rT3 might be a cause of the observed decrease in peripheral T3 generation in old subjects, acting by an inhibition of the T4-T3 conversion.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7180357

Citation

Szabolcs, I, et al. "The Possible Reason for Serum 3,3'5'-(reverse) Triiodothyronine Increase in Old People." Acta Medica Academiae Scientiarum Hungaricae, vol. 39, no. 1-2, 1982, pp. 11-7.
Szabolcs I, Weber M, Kovács Z, et al. The possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people. Acta Med Acad Sci Hung. 1982;39(1-2):11-7.
Szabolcs, I., Weber, M., Kovács, Z., Irsy, G., Góth, M., Halász, T., & Szilágyi, G. (1982). The possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people. Acta Medica Academiae Scientiarum Hungaricae, 39(1-2), 11-7.
Szabolcs I, et al. The Possible Reason for Serum 3,3'5'-(reverse) Triiodothyronine Increase in Old People. Acta Med Acad Sci Hung. 1982;39(1-2):11-7. PubMed PMID: 7180357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people. AU - Szabolcs,I, AU - Weber,M, AU - Kovács,Z, AU - Irsy,G, AU - Góth,M, AU - Halász,T, AU - Szilágyi,G, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 11 EP - 7 JF - Acta medica Academiae Scientiarum Hungaricae JO - Acta Med Acad Sci Hung VL - 39 IS - 1-2 N2 - Healthy subjects aged 70-90 and 20-40 years were investigated for the level of reverse triiodothyronine (rT3). The mean level in 57 old subjects was higher and the triiodothyronine (T3) level lower than in 30 young persons. No negative correlation was observed. A serum T3 elevation caused by liothyronine administration (5-15 micrograms/day for two weeks) was not followed by a change of the mean rT3 level in 12 old subjects. After a single intramuscular thyrotropin (TSH) injection, the rT3 elevation lasted 24h longer in 19 old persons than in the 9 control ones, though the early rT3 response was similar in both groups. Propranolol administration (40 mg t.i.d. for a week) caused a similar rT3 elevation in old persons (n = 18) as in 12 young ones. From the indirect data it is concluded that the serum rT3 elevation in old age is a result of faster peripheral generation and not of increased production in the thyroid gland. The data do not indicate any change of rT3 metabolism. T4-T3 and T4-rT3 conversion are provoked by different enzymes. The elevation of rT3 might be a cause of the observed decrease in peripheral T3 generation in old subjects, acting by an inhibition of the T4-T3 conversion. SN - 0001-5989 UR - https://www.unboundmedicine.com/medline/citation/7180357/The_possible_reason_for_serum_33'5'__reverse__triiodothyronine_increase_in_old_people_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -