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Predicted ovulatory response to 2-brom-alpha-ergocryptine (CB-154) in amenorrhea-galactorrhea syndromes.
Am J Obstet Gynecol. 1980 Mar 01; 136(5):652-8.AJ

Abstract

Adenohypophyseal function was evaluated in 20 consecutive patients with hyperprolactinemic amenorrhea-galactorrhea in an attempt to predict ovulatory response with 2-brom-alpha-ergocryptine (CB-154) therapy. Pituitary fossa tomography and response to insulin, thyrotropin-releasing hormone, and luteinizing hormone--releasing hormone were correlated with the return of ovulatory cycles. Fourteen of 15 patients demonstrating normal pretreatment sellar volume ovulated, compared with 0 of 5 showing increased volume. Thirteen of 14 with adequate adenophypophyseal reserve of growth hormone and luteinizing hormone ovulated, compared with 0 of 6 and 1 of 6, respectively, with inadequate reserve. Serum prolactin suppression to normal occurred in 19 of 20 patients but could not predict response. Only 2 of 10 patients receiving clomiphene citrate ovulated and neither conceived, while 8 of the 10 ovulated with CB-154 and 6 of 7 desiring pregnancy conceived. CB-154 is an effective "fertility drug" and response to therapy can usually be predicted.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

7188835

Citation

Shewchuk, A B., et al. "Predicted Ovulatory Response to 2-brom-alpha-ergocryptine (CB-154) in Amenorrhea-galactorrhea Syndromes." American Journal of Obstetrics and Gynecology, vol. 136, no. 5, 1980, pp. 652-8.
Shewchuk AB, Corenblum B, Pairaudeau N, et al. Predicted ovulatory response to 2-brom-alpha-ergocryptine (CB-154) in amenorrhea-galactorrhea syndromes. Am J Obstet Gynecol. 1980;136(5):652-8.
Shewchuk, A. B., Corenblum, B., Pairaudeau, N., Ezrin, C., & Adamson, G. D. (1980). Predicted ovulatory response to 2-brom-alpha-ergocryptine (CB-154) in amenorrhea-galactorrhea syndromes. American Journal of Obstetrics and Gynecology, 136(5), 652-8.
Shewchuk AB, et al. Predicted Ovulatory Response to 2-brom-alpha-ergocryptine (CB-154) in Amenorrhea-galactorrhea Syndromes. Am J Obstet Gynecol. 1980 Mar 1;136(5):652-8. PubMed PMID: 7188835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicted ovulatory response to 2-brom-alpha-ergocryptine (CB-154) in amenorrhea-galactorrhea syndromes. AU - Shewchuk,A B, AU - Corenblum,B, AU - Pairaudeau,N, AU - Ezrin,C, AU - Adamson,G D, PY - 1980/3/1/pubmed PY - 1980/3/1/medline PY - 1980/3/1/entrez SP - 652 EP - 8 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 136 IS - 5 N2 - Adenohypophyseal function was evaluated in 20 consecutive patients with hyperprolactinemic amenorrhea-galactorrhea in an attempt to predict ovulatory response with 2-brom-alpha-ergocryptine (CB-154) therapy. Pituitary fossa tomography and response to insulin, thyrotropin-releasing hormone, and luteinizing hormone--releasing hormone were correlated with the return of ovulatory cycles. Fourteen of 15 patients demonstrating normal pretreatment sellar volume ovulated, compared with 0 of 5 showing increased volume. Thirteen of 14 with adequate adenophypophyseal reserve of growth hormone and luteinizing hormone ovulated, compared with 0 of 6 and 1 of 6, respectively, with inadequate reserve. Serum prolactin suppression to normal occurred in 19 of 20 patients but could not predict response. Only 2 of 10 patients receiving clomiphene citrate ovulated and neither conceived, while 8 of the 10 ovulated with CB-154 and 6 of 7 desiring pregnancy conceived. CB-154 is an effective "fertility drug" and response to therapy can usually be predicted. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/7188835/Predicted_ovulatory_response_to_2_brom_alpha_ergocryptine__CB_154__in_amenorrhea_galactorrhea_syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(80)91019-4 DB - PRIME DP - Unbound Medicine ER -