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Mechanism of the Ménière attack.
ORL J Otorhinolaryngol Relat Spec. 1980; 42(1-2):10-9.OJ

Abstract

A survey of experimental evidence showing the influence of an increase in potassium concentration in the perilymph on cochlear and vestibular nerve branches is discussed. Informations have indicated that a concentration lower than 20--30 mM produced an increase in action potential frequency in nerve preparations and that a low potassium concentration in animal experiments produced an ipsilateral nystagmus. Increasing the concentration of potassium in the endolymph to values not over the normal endolymph concentration, blocked the conduction of action potentials in the vestibular nerve branches resulting in a reversible contralateral nystagmus. From these results it may be concluded that all objective symptoms of a Ménière attack can be experimentally reproduced by one single factor: the potassium concentration in the perilymph. The known ruptures in the distended walls in a hydrops, with a diffusion of endolymph potassium into the perilymph surrounding the nerve branches to the vestibular and cochlear areas have consequently been assumed to produce the basis for Ménière attacks.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7189270

Citation

Dohlman, G F.. "Mechanism of the Ménière Attack." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 42, no. 1-2, 1980, pp. 10-9.
Dohlman GF. Mechanism of the Ménière attack. ORL J Otorhinolaryngol Relat Spec. 1980;42(1-2):10-9.
Dohlman, G. F. (1980). Mechanism of the Ménière attack. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 42(1-2), 10-9.
Dohlman GF. Mechanism of the Ménière Attack. ORL J Otorhinolaryngol Relat Spec. 1980;42(1-2):10-9. PubMed PMID: 7189270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism of the Ménière attack. A1 - Dohlman,G F, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 10 EP - 9 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 42 IS - 1-2 N2 - A survey of experimental evidence showing the influence of an increase in potassium concentration in the perilymph on cochlear and vestibular nerve branches is discussed. Informations have indicated that a concentration lower than 20--30 mM produced an increase in action potential frequency in nerve preparations and that a low potassium concentration in animal experiments produced an ipsilateral nystagmus. Increasing the concentration of potassium in the endolymph to values not over the normal endolymph concentration, blocked the conduction of action potentials in the vestibular nerve branches resulting in a reversible contralateral nystagmus. From these results it may be concluded that all objective symptoms of a Ménière attack can be experimentally reproduced by one single factor: the potassium concentration in the perilymph. The known ruptures in the distended walls in a hydrops, with a diffusion of endolymph potassium into the perilymph surrounding the nerve branches to the vestibular and cochlear areas have consequently been assumed to produce the basis for Ménière attacks. SN - 0301-1569 UR - https://www.unboundmedicine.com/medline/citation/7189270/Mechanism_of_the_Ménière_attack_ L2 - https://www.karger.com?DOI=10.1159/000275476 DB - PRIME DP - Unbound Medicine ER -