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Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum.
J Nat Prod. 1980 Mar-Apr; 43(2):296-301.JN

Abstract

An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The chlorohydrin of O-methylpsorospermin 2 was also isolated after treatment of the fraction containing psorospermin chlorohydrin 6 with diazomethane. Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7189773

Citation

Kupchan, S M., et al. "Psorospermin, a New Antileukemic Xanthone From Psorospermum Febrifugum." Journal of Natural Products, vol. 43, no. 2, 1980, pp. 296-301.
Kupchan SM, Streelman DR, Sneden AT. Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum. J Nat Prod. 1980;43(2):296-301.
Kupchan, S. M., Streelman, D. R., & Sneden, A. T. (1980). Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum. Journal of Natural Products, 43(2), 296-301.
Kupchan SM, Streelman DR, Sneden AT. Psorospermin, a New Antileukemic Xanthone From Psorospermum Febrifugum. J Nat Prod. 1980 Mar-Apr;43(2):296-301. PubMed PMID: 7189773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum. AU - Kupchan,S M, AU - Streelman,D R, AU - Sneden,A T, PY - 1980/3/1/pubmed PY - 1980/3/1/medline PY - 1980/3/1/entrez SP - 296 EP - 301 JF - Journal of natural products JO - J Nat Prod VL - 43 IS - 2 N2 - An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The chlorohydrin of O-methylpsorospermin 2 was also isolated after treatment of the fraction containing psorospermin chlorohydrin 6 with diazomethane. Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/7189773/Psorospermin_a_new_antileukemic_xanthone_from_Psorospermum_febrifugum_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:7189773 DB - PRIME DP - Unbound Medicine ER -