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Prolactin-secreting pituitary adenomas. III. Frequency and diagnosis in amenorrhea-galactorrhea.
JAMA. 1980 Sep 19; 244(12):1329-32.JAMA

Abstract

Hypocycloidal tomograms of the sella turcica and serum prolactin concentrations were obtained in 146 women with amenorrhea, galactorrhea, or both to diagnose prolactin-secreting pituitary adenomas. Findings suggesting an adenoma, ie, abnormal tomogram and elevated serum prolactin concentration, were found in 24.6% (16/65) of previously unscreened patients and 59.2% (48/81) of prescreened patients. The combination of an abnormal tomogram and elevated prolactin level was relatively specific for an adenoma, as 91% (42/46) of women with these findings who underwent surgery had histologically confirmed tumors. Tumors occurred in women from 15 to 45 years of age, with amenorrhea or galactorrhea ranging from less than six months to more than 20 years in duration. Some women in this series also had obesity, rapid weight loss, polycystic ovarian syndrome, amenorrhea following discontinuance of oral contraceptive use, or emotional stress.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7191013

Citation

Keye, W R., et al. "Prolactin-secreting Pituitary Adenomas. III. Frequency and Diagnosis in Amenorrhea-galactorrhea." JAMA, vol. 244, no. 12, 1980, pp. 1329-32.
Keye WR, Chang RJ, Wilson CB, et al. Prolactin-secreting pituitary adenomas. III. Frequency and diagnosis in amenorrhea-galactorrhea. JAMA. 1980;244(12):1329-32.
Keye, W. R., Chang, R. J., Wilson, C. B., & Jaffe, R. B. (1980). Prolactin-secreting pituitary adenomas. III. Frequency and diagnosis in amenorrhea-galactorrhea. JAMA, 244(12), 1329-32.
Keye WR, et al. Prolactin-secreting Pituitary Adenomas. III. Frequency and Diagnosis in Amenorrhea-galactorrhea. JAMA. 1980 Sep 19;244(12):1329-32. PubMed PMID: 7191013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolactin-secreting pituitary adenomas. III. Frequency and diagnosis in amenorrhea-galactorrhea. AU - Keye,W R,Jr AU - Chang,R J, AU - Wilson,C B, AU - Jaffe,R B, PY - 1980/9/19/pubmed PY - 2001/3/28/medline PY - 1980/9/19/entrez SP - 1329 EP - 32 JF - JAMA JO - JAMA VL - 244 IS - 12 N2 - Hypocycloidal tomograms of the sella turcica and serum prolactin concentrations were obtained in 146 women with amenorrhea, galactorrhea, or both to diagnose prolactin-secreting pituitary adenomas. Findings suggesting an adenoma, ie, abnormal tomogram and elevated serum prolactin concentration, were found in 24.6% (16/65) of previously unscreened patients and 59.2% (48/81) of prescreened patients. The combination of an abnormal tomogram and elevated prolactin level was relatively specific for an adenoma, as 91% (42/46) of women with these findings who underwent surgery had histologically confirmed tumors. Tumors occurred in women from 15 to 45 years of age, with amenorrhea or galactorrhea ranging from less than six months to more than 20 years in duration. Some women in this series also had obesity, rapid weight loss, polycystic ovarian syndrome, amenorrhea following discontinuance of oral contraceptive use, or emotional stress. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/7191013/Prolactin_secreting_pituitary_adenomas__III__Frequency_and_diagnosis_in_amenorrhea_galactorrhea_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/244/pg/1329 DB - PRIME DP - Unbound Medicine ER -