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[Correction of the symptoms of hereditary galactosemia in W/SSM strain rats by enzymatic imprinting].
Genetika. 1982 Mar; 18(3):428-33.G

Abstract

It was recently shown in this laboratory that treatment of newborn animals with certain enzymic inducers causes stable changes in the activities of the inducible enzymes at a later adult stage. Cataracts, hepato-splenomegaly and other galactosemia symptoms in galactosemic W/SSM rats develop spontaneously. The increased uptake of galactose by erythrocytes, but not the decreased level of galactose-1-phosphate uridyl transferase (Gal-1-PUT) activity was assumed to be the major cause of the disease. The administration of galactose to the newborn W/SSM rats (2 mg/g of body weight for 14 days) resulted in a sustained decline in the uptake of 14C-galactose by erythrocytes at least for five months, in an increase of glucoso-6-phosphate dehydrogenase activity and in a continuous fall of Gal-1-PUT activity. The neonatal treatment of the galactosemic rats with galactose abolished the main symptoms of galactosemia (cararacts, hepato-splenomegally) in adult animals, perhaps ar a consequence of the stable changes in the galactose metabolism.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

rus

PubMed ID

7200439

Citation

Salganik, R I., et al. "[Correction of the Symptoms of Hereditary Galactosemia in W/SSM Strain Rats By Enzymatic Imprinting]." Genetika, vol. 18, no. 3, 1982, pp. 428-33.
Salganik RI, Solov'eva NA, Kandaurov VV. [Correction of the symptoms of hereditary galactosemia in W/SSM strain rats by enzymatic imprinting]. Genetika. 1982;18(3):428-33.
Salganik, R. I., Solov'eva, N. A., & Kandaurov, V. V. (1982). [Correction of the symptoms of hereditary galactosemia in W/SSM strain rats by enzymatic imprinting]. Genetika, 18(3), 428-33.
Salganik RI, Solov'eva NA, Kandaurov VV. [Correction of the Symptoms of Hereditary Galactosemia in W/SSM Strain Rats By Enzymatic Imprinting]. Genetika. 1982;18(3):428-33. PubMed PMID: 7200439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Correction of the symptoms of hereditary galactosemia in W/SSM strain rats by enzymatic imprinting]. AU - Salganik,R I, AU - Solov'eva,N A, AU - Kandaurov,V V, PY - 1982/3/1/pubmed PY - 1982/3/1/medline PY - 1982/3/1/entrez SP - 428 EP - 33 JF - Genetika JO - Genetika VL - 18 IS - 3 N2 - It was recently shown in this laboratory that treatment of newborn animals with certain enzymic inducers causes stable changes in the activities of the inducible enzymes at a later adult stage. Cataracts, hepato-splenomegaly and other galactosemia symptoms in galactosemic W/SSM rats develop spontaneously. The increased uptake of galactose by erythrocytes, but not the decreased level of galactose-1-phosphate uridyl transferase (Gal-1-PUT) activity was assumed to be the major cause of the disease. The administration of galactose to the newborn W/SSM rats (2 mg/g of body weight for 14 days) resulted in a sustained decline in the uptake of 14C-galactose by erythrocytes at least for five months, in an increase of glucoso-6-phosphate dehydrogenase activity and in a continuous fall of Gal-1-PUT activity. The neonatal treatment of the galactosemic rats with galactose abolished the main symptoms of galactosemia (cararacts, hepato-splenomegally) in adult animals, perhaps ar a consequence of the stable changes in the galactose metabolism. SN - 0016-6758 UR - https://www.unboundmedicine.com/medline/citation/7200439/[Correction_of_the_symptoms_of_hereditary_galactosemia_in_W/SSM_strain_rats_by_enzymatic_imprinting]_ L2 - https://antibodies.cancer.gov/detail/CPTC-AKR1B1-1 DB - PRIME DP - Unbound Medicine ER -