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Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis.
Neurology. 1981 Oct; 31(10):1263-70.Neur

Abstract

An immunosuppressed child with acute lymphoblastic leukemia in clinical remission developed measles inclusion body encephalitis (MIBE). Although measles antigen and nonbudding measles virus nucleocapsids were detected in brain tissue, no virus was isolated. Immune precipitation of measles virus proteins with the patient's serum showed no detectable antibody to virus M protein, a finding that has been reported in subacute sclerosing panencephalitis (SSPE). The virologic and immune precipitation studies suggest a similar virus mutation in MIBE and SSPE. The pathogenesis of the two diseases may also be similar.

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Authors

Roos RP
No affiliation info available
Graves MC
No affiliation info available
Wollmann RL
No affiliation info available
Chilcote RR
No affiliation info available
Nixon J
No affiliation info available

MeSH

AdultAntibodies, ViralAntigens, ViralBrainEncephalitisFemaleHumansImmunosuppressionInclusion Bodies, ViralMeaslesMeasles virusSSPE VirusSubacute Sclerosing PanencephalitisViral Proteins

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7202137

Citation

Roos, R P., et al. "Immunologic and Virologic Studies of Measles Inclusion Body Encephalitis in an Immunosuppressed Host: the Relationship to Subacute Sclerosing Panencephalitis." Neurology, vol. 31, no. 10, 1981, pp. 1263-70.
Roos RP, Graves MC, Wollmann RL, et al. Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis. Neurology. 1981;31(10):1263-70.
Roos, R. P., Graves, M. C., Wollmann, R. L., Chilcote, R. R., & Nixon, J. (1981). Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis. Neurology, 31(10), 1263-70.
Roos RP, et al. Immunologic and Virologic Studies of Measles Inclusion Body Encephalitis in an Immunosuppressed Host: the Relationship to Subacute Sclerosing Panencephalitis. Neurology. 1981;31(10):1263-70. PubMed PMID: 7202137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis. AU - Roos,R P, AU - Graves,M C, AU - Wollmann,R L, AU - Chilcote,R R, AU - Nixon,J, PY - 1981/10/1/pubmed PY - 1981/10/1/medline PY - 1981/10/1/entrez SP - 1263 EP - 70 JF - Neurology JO - Neurology VL - 31 IS - 10 N2 - An immunosuppressed child with acute lymphoblastic leukemia in clinical remission developed measles inclusion body encephalitis (MIBE). Although measles antigen and nonbudding measles virus nucleocapsids were detected in brain tissue, no virus was isolated. Immune precipitation of measles virus proteins with the patient's serum showed no detectable antibody to virus M protein, a finding that has been reported in subacute sclerosing panencephalitis (SSPE). The virologic and immune precipitation studies suggest a similar virus mutation in MIBE and SSPE. The pathogenesis of the two diseases may also be similar. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/7202137/Immunologic_and_virologic_studies_of_measles_inclusion_body_encephalitis_in_an_immunosuppressed_host:_the_relationship_to_subacute_sclerosing_panencephalitis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7202137.ui DB - PRIME DP - Unbound Medicine ER -