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Oral contraceptives and breast disease in premenopausal Northern Albertan women.

Abstract

The results of a prospective study on oral contraceptive use and breast disease in northern Alberta are presented. The study groups comprised all women aged 30 to 49 examined in diagnostic breast clinics at the Cross Cancer Institute between 1971 and 1974. Three hundred and one patients had breast cancer, 692 had a subsequent biopsy for a benign breast condition, and 548 had no subsequent biopsy. A tendency for an increased relative risk (RR) of breast cancer in women taking oral contraceptives for periods of 1 to 5 years was evident, with relative risk decreased or unaffected in users of less than 12 months (RR = 0.6) or more than 5 years (RR = 1.0). A slightly increased risk was apparent in patients using oral contraceptives within a year prior to attendance at the clinic (recent users); this increase was emphasized when recent users with a prior biopsy for benign breast disease were analyzed alone (RR = 5.0). In women with a prior breast biopsy, use of oral contraceptives for more than 5 years increased risk of breast cancer nine-fold. Former users who had taken oral contraceptives for less than a year showed a significant reduction in breast cancer risk (RR = 0.3). The risk of benign breast disease was also reduced in former users (RR = 0.6) as well as in long-term users (RR = 0.5).

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  • Publisher Full Text
  • Authors

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    Source

    International journal of cancer 22:6 1978 Dec pg 700-7

    MeSH

    Adult
    Age Factors
    Alberta
    Breast
    Breast Neoplasms
    Contraceptives, Oral
    Female
    Humans
    Menopause
    Middle Aged
    Prospective Studies
    Risk
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    721325

    Citation

    Lees, A W., et al. "Oral Contraceptives and Breast Disease in Premenopausal Northern Albertan Women." International Journal of Cancer, vol. 22, no. 6, 1978, pp. 700-7.
    Lees AW, Burns PE, Grace M. Oral contraceptives and breast disease in premenopausal Northern Albertan women. Int J Cancer. 1978;22(6):700-7.
    Lees, A. W., Burns, P. E., & Grace, M. (1978). Oral contraceptives and breast disease in premenopausal Northern Albertan women. International Journal of Cancer, 22(6), pp. 700-7.
    Lees AW, Burns PE, Grace M. Oral Contraceptives and Breast Disease in Premenopausal Northern Albertan Women. Int J Cancer. 1978;22(6):700-7. PubMed PMID: 721325.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oral contraceptives and breast disease in premenopausal Northern Albertan women. AU - Lees,A W, AU - Burns,P E, AU - Grace,M, PY - 1978/12/1/pubmed PY - 1978/12/1/medline PY - 1978/12/1/entrez KW - Age Factors KW - Biology KW - Breast Cancer KW - Cancer KW - Contraception KW - Contraceptive Methods--side effects KW - Diseases KW - Family Planning KW - Fibroadenosis KW - Histology KW - Neoplasms KW - Oral Contraceptives--side effects KW - Parity KW - Prospective Studies KW - Research Methodology KW - Studies SP - 700 EP - 7 JF - International journal of cancer JO - Int. J. Cancer VL - 22 IS - 6 N2 - The results of a prospective study on oral contraceptive use and breast disease in northern Alberta are presented. The study groups comprised all women aged 30 to 49 examined in diagnostic breast clinics at the Cross Cancer Institute between 1971 and 1974. Three hundred and one patients had breast cancer, 692 had a subsequent biopsy for a benign breast condition, and 548 had no subsequent biopsy. A tendency for an increased relative risk (RR) of breast cancer in women taking oral contraceptives for periods of 1 to 5 years was evident, with relative risk decreased or unaffected in users of less than 12 months (RR = 0.6) or more than 5 years (RR = 1.0). A slightly increased risk was apparent in patients using oral contraceptives within a year prior to attendance at the clinic (recent users); this increase was emphasized when recent users with a prior biopsy for benign breast disease were analyzed alone (RR = 5.0). In women with a prior breast biopsy, use of oral contraceptives for more than 5 years increased risk of breast cancer nine-fold. Former users who had taken oral contraceptives for less than a year showed a significant reduction in breast cancer risk (RR = 0.3). The risk of benign breast disease was also reduced in former users (RR = 0.6) as well as in long-term users (RR = 0.5). SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/721325/Oral_contraceptives_and_breast_disease_in_premenopausal_Northern_Albertan_women_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1978&volume=22&issue=6&spage=700 DB - PRIME DP - Unbound Medicine ER -