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Effect of erythromycin base on theophylline kinetics.
Clin Pharmacol Ther. 1981 May; 29(5):601-5.CP

Abstract

Because of several recent reports describing altered theophylline elimination in the presence of salts of erythromycin, the effect of a 10-day course of erythromycin base on theophylline kinetics was studied in eight healthy adult men. Theophylline (4 mg/kg) was given on four separate study days: (1) prior to starting erythromycin, (2) on the third day of erythromycin administration, (3) on the tenth day of erythromycin administration, and (4) 2 weeks after the course of erythromycin was completed. Mean theophylline kinetic parameter values on each of the 4 study days were: apparent volume of distribution (Vd), 0.466, 0.466, 0.472, and 0.470 1/kg; elimination half-life (t1/2), 7.4, 7.8, 8.5, and 7.0 hr; and total body clearance (ClB), 0.747, 0.723, 0.683, and 0.821 ml/min/kg. A maximum decrease of 20.7% in theophylline ClB was noted by the third study day. Two weeks after erythromycin was discontinued, the greatest increase in ClB observed was 45.7%. Differences in t1/2 and ClB between the third and fourth study days were statistically significant (p less than 0.05).

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7214790

Citation

Zarowitz, B J., et al. "Effect of Erythromycin Base On Theophylline Kinetics." Clinical Pharmacology and Therapeutics, vol. 29, no. 5, 1981, pp. 601-5.
Zarowitz BJ, Szefler SJ, Lasezkay GM. Effect of erythromycin base on theophylline kinetics. Clin Pharmacol Ther. 1981;29(5):601-5.
Zarowitz, B. J., Szefler, S. J., & Lasezkay, G. M. (1981). Effect of erythromycin base on theophylline kinetics. Clinical Pharmacology and Therapeutics, 29(5), 601-5.
Zarowitz BJ, Szefler SJ, Lasezkay GM. Effect of Erythromycin Base On Theophylline Kinetics. Clin Pharmacol Ther. 1981;29(5):601-5. PubMed PMID: 7214790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of erythromycin base on theophylline kinetics. AU - Zarowitz,B J, AU - Szefler,S J, AU - Lasezkay,G M, PY - 1981/5/1/pubmed PY - 1981/5/1/medline PY - 1981/5/1/entrez SP - 601 EP - 5 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 29 IS - 5 N2 - Because of several recent reports describing altered theophylline elimination in the presence of salts of erythromycin, the effect of a 10-day course of erythromycin base on theophylline kinetics was studied in eight healthy adult men. Theophylline (4 mg/kg) was given on four separate study days: (1) prior to starting erythromycin, (2) on the third day of erythromycin administration, (3) on the tenth day of erythromycin administration, and (4) 2 weeks after the course of erythromycin was completed. Mean theophylline kinetic parameter values on each of the 4 study days were: apparent volume of distribution (Vd), 0.466, 0.466, 0.472, and 0.470 1/kg; elimination half-life (t1/2), 7.4, 7.8, 8.5, and 7.0 hr; and total body clearance (ClB), 0.747, 0.723, 0.683, and 0.821 ml/min/kg. A maximum decrease of 20.7% in theophylline ClB was noted by the third study day. Two weeks after erythromycin was discontinued, the greatest increase in ClB observed was 45.7%. Differences in t1/2 and ClB between the third and fourth study days were statistically significant (p less than 0.05). SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/7214790/Effect_of_erythromycin_base_on_theophylline_kinetics_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9236&date=1981&volume=29&issue=5&spage=601 DB - PRIME DP - Unbound Medicine ER -