Urine composition in patients with urolithiasis during treatment with magnesium oxide.Urol Res. 1980; 8(4):197-206.UR
Fifteen patients with recurrent renal stone formation were treated with 400 mg magnesium oxide daily. Urine composition was analyzed before the start of treatment and after 6-12 months. The urinary excretion of magnesium before and during treatment was 321 +/- 120 (mean +/- SD) and 409 +/- 140 mmol per mol creatinine respectively, a difference that was not statistically significant. Urinary calcium increased from 473 +/- 186 to 662 +/- 213 mmol per mol creatinine (p less than 0.05). All patients who increased their excretion of magnesium also increased the urinary output of calcium and, as a result of this, the calcium/magnesium-quotients were unaffected by the treatment. No significant effect was observed on urine oxalate excretion. Serum concentrations of calcium, magnesium and urate all remained at the pre-treatment level. From the results obtained in this study, magnesium oxide in this dosage cannot be recommended for use in treatment of patients with urolithiasis.