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Urine composition in patients with urolithiasis during treatment with magnesium oxide.
Urol Res. 1980; 8(4):197-206.UR

Abstract

Fifteen patients with recurrent renal stone formation were treated with 400 mg magnesium oxide daily. Urine composition was analyzed before the start of treatment and after 6-12 months. The urinary excretion of magnesium before and during treatment was 321 +/- 120 (mean +/- SD) and 409 +/- 140 mmol per mol creatinine respectively, a difference that was not statistically significant. Urinary calcium increased from 473 +/- 186 to 662 +/- 213 mmol per mol creatinine (p less than 0.05). All patients who increased their excretion of magnesium also increased the urinary output of calcium and, as a result of this, the calcium/magnesium-quotients were unaffected by the treatment. No significant effect was observed on urine oxalate excretion. Serum concentrations of calcium, magnesium and urate all remained at the pre-treatment level. From the results obtained in this study, magnesium oxide in this dosage cannot be recommended for use in treatment of patients with urolithiasis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7222314

Citation

Tiselius, H G., et al. "Urine Composition in Patients With Urolithiasis During Treatment With Magnesium Oxide." Urological Research, vol. 8, no. 4, 1980, pp. 197-206.
Tiselius HG, Ahlstrand C, Larsson L. Urine composition in patients with urolithiasis during treatment with magnesium oxide. Urol Res. 1980;8(4):197-206.
Tiselius, H. G., Ahlstrand, C., & Larsson, L. (1980). Urine composition in patients with urolithiasis during treatment with magnesium oxide. Urological Research, 8(4), 197-206.
Tiselius HG, Ahlstrand C, Larsson L. Urine Composition in Patients With Urolithiasis During Treatment With Magnesium Oxide. Urol Res. 1980;8(4):197-206. PubMed PMID: 7222314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urine composition in patients with urolithiasis during treatment with magnesium oxide. AU - Tiselius,H G, AU - Ahlstrand,C, AU - Larsson,L, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 197 EP - 206 JF - Urological research JO - Urol. Res. VL - 8 IS - 4 N2 - Fifteen patients with recurrent renal stone formation were treated with 400 mg magnesium oxide daily. Urine composition was analyzed before the start of treatment and after 6-12 months. The urinary excretion of magnesium before and during treatment was 321 +/- 120 (mean +/- SD) and 409 +/- 140 mmol per mol creatinine respectively, a difference that was not statistically significant. Urinary calcium increased from 473 +/- 186 to 662 +/- 213 mmol per mol creatinine (p less than 0.05). All patients who increased their excretion of magnesium also increased the urinary output of calcium and, as a result of this, the calcium/magnesium-quotients were unaffected by the treatment. No significant effect was observed on urine oxalate excretion. Serum concentrations of calcium, magnesium and urate all remained at the pre-treatment level. From the results obtained in this study, magnesium oxide in this dosage cannot be recommended for use in treatment of patients with urolithiasis. SN - 0300-5623 UR - https://www.unboundmedicine.com/medline/citation/7222314/Urine_composition_in_patients_with_urolithiasis_during_treatment_with_magnesium_oxide_ DB - PRIME DP - Unbound Medicine ER -