Tags

Type your tag names separated by a space and hit enter

An improved method for determining neutralizing antibody against lymphocytic choriomeningitis virus in human sera.
J Gen Virol. 1978 Nov; 41(2):377-83.JG

Abstract

Human antibody neutralizing lymphocytic choriomeningitis virus is most reliably determined in mice as assay hosts. Whereas the previously recommended procedure yielding a neutralization index requires much serum, the method described here uses only 0.1 ml. An equal mixture of virus and serum is incubated and residual infectivity is titrated intracerebrally in mice. The neutralizing activity is given by the ratio of virus surviving after incubation with control serum and with the test serum respectively. This ratio is called the neutralization factor.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

722285

Citation

Lehmann-Grube, F. "An Improved Method for Determining Neutralizing Antibody Against Lymphocytic Choriomeningitis Virus in Human Sera." The Journal of General Virology, vol. 41, no. 2, 1978, pp. 377-83.
Lehmann-Grube F. An improved method for determining neutralizing antibody against lymphocytic choriomeningitis virus in human sera. J Gen Virol. 1978;41(2):377-83.
Lehmann-Grube, F. (1978). An improved method for determining neutralizing antibody against lymphocytic choriomeningitis virus in human sera. The Journal of General Virology, 41(2), 377-83.
Lehmann-Grube F. An Improved Method for Determining Neutralizing Antibody Against Lymphocytic Choriomeningitis Virus in Human Sera. J Gen Virol. 1978;41(2):377-83. PubMed PMID: 722285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An improved method for determining neutralizing antibody against lymphocytic choriomeningitis virus in human sera. A1 - Lehmann-Grube,F, PY - 1978/11/1/pubmed PY - 1978/11/1/medline PY - 1978/11/1/entrez SP - 377 EP - 83 JF - The Journal of general virology JO - J Gen Virol VL - 41 IS - 2 N2 - Human antibody neutralizing lymphocytic choriomeningitis virus is most reliably determined in mice as assay hosts. Whereas the previously recommended procedure yielding a neutralization index requires much serum, the method described here uses only 0.1 ml. An equal mixture of virus and serum is incubated and residual infectivity is titrated intracerebrally in mice. The neutralizing activity is given by the ratio of virus surviving after incubation with control serum and with the test serum respectively. This ratio is called the neutralization factor. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/722285/An_improved_method_for_determining_neutralizing_antibody_against_lymphocytic_choriomeningitis_virus_in_human_sera_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/0022-1317-41-2-377 DB - PRIME DP - Unbound Medicine ER -