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[Changes in autonomic functions in diabetic neuropathy: cardiovascular reflexes and sweating].
Schweiz Med Wochenschr. 1981 May 09; 111(19):669-75.SM

Abstract

Failure of autonomic functions in diabetes has been investigated. Cardiovascular reflexes, and thermoregulation during heat exposure, were studied in 11 diabetic patients. Five had clinical signs of sensorimotor neuropathy and 6 served as age- and sex-matched controls. The subjects were studied by the following tests: orthostatic test, Valsalva, beat-to-beat variation during normal and forced respiration, and analysis of urinary catecholamines. Thermoregulation was measured for 80 minutes, at an ambient temperature of 37 degrees C, in a gradient layer direct calorimeter measuring evaporative heat losses with a precision of +/- 1 watt. The cardiovascular tests showed a relationship between the sensorimotor defects and the autonomic dysfunctions. The beat-to-beat variation was found to be the most sensitive test, the Valsalva and orthostatic test being respectively less so. However, the diabetic patients' autonomic disorders were not associated with a significant decrease in evaporative heat losses. The internal temperature (esophageal) at which sweating began (set point) was higher in some of the neuropathic diabetics than in the controls. Once the set point had been reached, however, the increase in evaporative heat losses was greater in diabetics than in controls. These findings can be accounted for by zones of compensatory hypersweating in patients with polyneuropathy. The changes in evaporative heat loss pattern may represent an early alteration in autonomic diabetic neuropathy.

Authors

Grimm JJ
No affiliation info available
Jéquier E
No affiliation info available
Regli F
No affiliation info available

MeSH

AdultAutonomic Nervous SystemBody Temperature RegulationCardiovascular SystemCatecholaminesDiabetic NeuropathiesElectrocardiographyHeart RateHumansHypotension, OrthostaticMaleReflexSkin TemperatureSweatingValsalva Maneuver

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

7233138

Citation

Grimm, J J., et al. "[Changes in Autonomic Functions in Diabetic Neuropathy: Cardiovascular Reflexes and Sweating]." Schweizerische Medizinische Wochenschrift, vol. 111, no. 19, 1981, pp. 669-75.
Grimm JJ, Jéquier E, Regli F. [Changes in autonomic functions in diabetic neuropathy: cardiovascular reflexes and sweating]. Schweiz Med Wochenschr. 1981;111(19):669-75.
Grimm, J. J., Jéquier, E., & Regli, F. (1981). [Changes in autonomic functions in diabetic neuropathy: cardiovascular reflexes and sweating]. Schweizerische Medizinische Wochenschrift, 111(19), 669-75.
Grimm JJ, Jéquier E, Regli F. [Changes in Autonomic Functions in Diabetic Neuropathy: Cardiovascular Reflexes and Sweating]. Schweiz Med Wochenschr. 1981 May 9;111(19):669-75. PubMed PMID: 7233138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes in autonomic functions in diabetic neuropathy: cardiovascular reflexes and sweating]. AU - Grimm,J J, AU - Jéquier,E, AU - Regli,F, PY - 1981/5/9/pubmed PY - 1981/5/9/medline PY - 1981/5/9/entrez SP - 669 EP - 75 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 111 IS - 19 N2 - Failure of autonomic functions in diabetes has been investigated. Cardiovascular reflexes, and thermoregulation during heat exposure, were studied in 11 diabetic patients. Five had clinical signs of sensorimotor neuropathy and 6 served as age- and sex-matched controls. The subjects were studied by the following tests: orthostatic test, Valsalva, beat-to-beat variation during normal and forced respiration, and analysis of urinary catecholamines. Thermoregulation was measured for 80 minutes, at an ambient temperature of 37 degrees C, in a gradient layer direct calorimeter measuring evaporative heat losses with a precision of +/- 1 watt. The cardiovascular tests showed a relationship between the sensorimotor defects and the autonomic dysfunctions. The beat-to-beat variation was found to be the most sensitive test, the Valsalva and orthostatic test being respectively less so. However, the diabetic patients' autonomic disorders were not associated with a significant decrease in evaporative heat losses. The internal temperature (esophageal) at which sweating began (set point) was higher in some of the neuropathic diabetics than in the controls. Once the set point had been reached, however, the increase in evaporative heat losses was greater in diabetics than in controls. These findings can be accounted for by zones of compensatory hypersweating in patients with polyneuropathy. The changes in evaporative heat loss pattern may represent an early alteration in autonomic diabetic neuropathy. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/7233138/[Changes_in_autonomic_functions_in_diabetic_neuropathy:_cardiovascular_reflexes_and_sweating]_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -